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Table 2 The names, Moa, and targets of the 30 drugs

From: Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis

Drug name

Moa

Target name

Adenosine

Adenosine receptor agonist

ADORA1|ADORA2A|ADORA2B|ADORA3|PI4K2A|PI4K2B|TRPM4

Anagrelide

Phosphodiesterase inhibitor

PDE3A

Arctigenin

MEK inhibitor

ADIPOR1|AHR|CHUK|MAP2K1

Azacitidine

DNA inhibitor

DNMT1|DNMT3A

Azacitidine

DNA methyltransferase inhibitor

DNMT1|DNMT3A

Beclomethasone-dipropionate

Immunosuppressant|Glucocorticoid receptor agonist

NR3C1|CYP3A5|ADGRG3

Benzonatate

Anesthetic—local

SCN5A

Cholic-acid

Bile acid

CES1|FECH|PLA2G1B|ADH1C|COX1|COX2|COX3|COX4I1|COX5A|COX5B|COX6A2|COX6B1|COX6C|COX7A1|COX7B|COX7C|COX8A|ESRRG|FABP6|GPBAR1

Clofarabine

Ribonucleoside reductase inhibitor

RRM1|POLA1|RRM2|SLC22A8|POLD1|POLE|RRM2B

Cycloheximide

Protein synthesis inhibitor

GSK3B|RPL3

Epothilone

Tubulin inhibitor

TUBB

Etoposide

Topoisomerase inhibitor

TOP2A|TOP2B|CYP2E1|CYP3A5

Gliquidone

Sulfonylurea

ABCC8|KCNJ11|KCNJ10|KCNJ8

GSK-1070916

Aurora kinase inhibitor

AURKB|AURKC|AURKA|CYP2D6|CYP3A4

GSK-429286A

Rho associated kinase inhibitor

ROCK1

Imatinib

PDGFR inhibitor|Bcr-Abl inhibitor|KIT inhibitor

ABL1|KIT|PDGFRA|BCR|CSF1R|PDGFRB|ABCG2|CYP2C19|CYP2C8|CYP3A5|DDR1|NTRK1|RET

Isoflupredone-acetate

Glucocorticoid receptor agonist

NR3C1

KIN001-244

PDK1 Inhibitor

PDPK1

KN-62

Calcium channel blocker|Purinergic receptor antagonist

P2RX7|CAMK2A|AKT1|CHEK1|LCK|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|PRKCA|ROCK1|RPS6KB1|SGK1

Lupanine

Sodium channel inhibitor

INS

Mitoxantrone

Topoisomerase inhibitor

TOP2A|PIM1

Nateglinide

Insulin secretagogue

ABCC8|KCNJ11|CYP3A4|INS|KCNJ10|PPARG

Nifedipine

Calcium channel blocker

CACNA1C|CACNA1D|CACNA1S|CACNA1F|CACNA2D1|CYP3A5|CACNA1H|CACNB2|CALM1|GLRA1|GLRA3|GLRB|KCNA1|KCNA5|NR1I2|TRPM3

Nimodipine

Calcium channel blocker

CACNA1C|NR3C2|CACNA1D|CACNA1F|CACNA1S|AHR|CACNB1|CACNB2|CACNB3|CACNB4|CFTR

Oxybenzone

Lipase inhibitor

LIPE

Phenacetin

Cyclooxygenase inhibitor

PTGS1

PLX-4720

RAF inhibitor

BRAF|KDR

SB-216763

GSK inhibitor

GSK3B|CCNA2|CDK2|GSK3A

SB-756050

G protein-coupled receptor agonist

GPBAR1

Tanaproget

Progesterone receptor agonist

PGR