Fig. 4

Knockdown of CENP-N affects the expression of proteins related to the AKT/mTOR signaling pathway, cell apoptosis, DNA damage, and the cell cycle in NPC cells. A, B Western blot detected AKT/mTOR pathway-related proteins expression in cells treated with CENP-N knockdown and/or radiotherapy. C, D Western blot detected Bax, γH2AX, and Cyclin D1 expression following CENP-N knockdown and/or radiotherapy. *p < 0.05, **p < 0.01, ***p < 0.001