Table 1 Characteristics of included studies
Author | Year of publication | Clinical trial registration | Sample size (control; intervention) | Weight (%) | Blinding | CHF cause | Route of delivery | Donor | cell origin | Cell number (mean) | Modality | Patients did not complete the study | Follow- up duration(month) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mohyeddin [20] | 2007 | FWA00001331 | 8;8 | 0.95 | _ | IH | IC & IM | Auto | BM | 5,550,000 | Echo, Spect | 0 | 18.5 |
Bartunek [21] | 2013 | NCT00810238 | 15;21 | 2.14 | SB | IH | IM | Auto | BM | 733,000,000 | Echo | 3 | 24 |
Heldman [10] | 2014 | NCT00768066 | 11;19 | 1.78 | DB | IH | TE | Auto | BM | 200,000,000 | Echo, MRI | 3 | 12 |
Perin [19] | 2015 | NCT00721045 | 5;15 | 3.56 | SB | IH & nIH | TE | Allo | BM | 25,000,000 | Echo, Spect | 6 | 36 |
5;15 | 75,000,000 | ||||||||||||
5;15 | 100,000,000 | ||||||||||||
Mathiasen [22] | 2015 | NCT00644410 | 20;40 | 3.56 | DB | IH | IM | Auto | BM | 77,500,000 | MRI | 5 | 6 |
Zhao [23] | 2015 | #122101310500 | 29;30 | 3.50 | NB | IH & nIH | IC | Allo | UC | _ | _ | _ | 6 |
Bartunek [25] | 2016 | NCT01768702 | 151;120 | 16.09 | DB | IH | IM | Auto | BM | > 24,000,000 | Echo | 28 | 39 |
Bartolucci [24] | 2017 | NCT01739777 | 15;15 | 1.78 | DB | IH & nIH | IV | Allo | UC | 1000000/kg | Echo, MRI | 2 | 12 |
Xiao [26] | 2017 | _ | 20;17 | 2.20 | NB | nIH | IC | Auto | BM | 490,000,000 | Echo, Spect | 4 | 12 |
Qayyum [27] | 2019 | NCT01449032 | 13;28 | 2.43 | DB | IH | IM | Auto | AT | 72,000,000 | MRI | 1 | 36 |
Yau [28] | 2019 | NCT02362646 | 53;106 | 9.44 | DB | IH & nIH | IM | Allo | BM | 150,000,000 | Echo | 62 | 12 |
Ulus [30] | 2020 | NCT02323477 | 16;26 | 2.49 | SB | IH | IM | Allo | UC | 23,000,000 | Echo, MRI, Spect | 4 | 12 |
Bolli [29] | 2020 | NCT02509156 | 17;14 | 1.84 | DB | nIH | TE | Allo | BM | 100,000,000 | MRI | 3 | 52.1 |
Bolli [31] | 2021 | NCT02501811 | 32;29 | 3.62 | DB | IH | TE | Auto | BM | 108,000,000 | MRI | 16 | 12 |
Qayyum1 [32] | 2023 | NCT03092284 | 27;54 | 4.81 | DB | IH | IM | Allo | AT | 100,000,000 | Echo | 6 | 12 |
Qayyum2 [33] | 2023 | NCT02673164 | 43;90 | 7.90 | DB | IH | IM | Allo | AT | 100,000,000 | Echo | 8 | 12 |
Perin [34] | 2023 | NCT02032004 | 272;265 | 31.89 | DB | IH & nIH | TE | Allo | BM | 150,000,000 | Echo | 0 | 30 |