Fig. 4

Construction of the CCRGPI. A Schematic diagram of CCRGPI construction. B LASSO regression analysis of the pairLRs. C Univariate Cox analysis of the pairLRs and stepwise Cox regression of the pairLRs significant in the univariate Cox analysis (p < 0.05). D PairLRs contained in the CCRGPI. E Kaplan‒Meier survival analysis of the pairLRs contained in the CCRGPI. CCRGPI cancer-associated fibroblast (CAF)-cancer cell crosstalk-related gene prognostic index, LASSO least absolute shrinkage and selection operator, pairLRs paired ligands and receptors