Fig. 6

Bergenin encapsulated in 3D biological scaffold can reduce collagenase-induced brain damage in ICH rats. (A-C) Representative images of hemorrhagic lesions, HE staining, and Masson staining results in rats from different groups. (D) TEM was used to examine the mitochondrial morphology of rats in different groups. (E) Nissl staining results of rats in different groups (n = 4). (F) Brain water content was measured to assess the effect of treatment on cerebral edema (n = 4). Scale bars: B and C, 200 μm /50µm; D, 4 nm /1nm. Data were expressed as mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001