Fig. 4

Integrative analysis of blood multi-omics data. A Integrative network plot of cytokines, immune cells, LC–MS and FIA metabolites in HC group (n = 46) by using xMWAS, correlation higher than 0.7, one color representing one community. B Integrative network plot of cytokines, immune cells, LC–MS and FIA metabolites in NMOSD group (n = 34) by using xMWAS, correlation higher than 0.7, one color representing one community. C The identification of nodes that undergo network changes, which is determined based on the Delta centrality (importance) measure (ECMnmo—ECMcontrol) in which EMC represents eigenvector centrality measure