Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.

You are viewing the site in preview mode

Skip to main content
Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model

Fig. 2

A The schematic Illustration of animal studies. B Human immune system multilineage development: FACS analysis of the human CD45 + cell fraction in the peripheral blood of humanized mice − 2, -1 and 0 weeks after humanization. C Engraftment efficiency (%graft) between the different groups. %graft was calculated as the proportion of human CD45+cells in the total CD45+cell population (human and mouse) in peripheral blood. D In-vivo depletion of endogenous Myeloid-derived suppressor cells (MDSCs) with Gr-1 antibody, and the proportion of MDSCs (CD11b and Gr-1 positive) decreased after intervention. E The photographs images of ankles between huPBMC-AIA and control group (0 day, 3 days, 7days). F Average paw thickness in huPBMC-AIA and control group after different treatments, summary of 3 independent replicate experiments (n = 15). G Top 5 enrichment analysis of biological processes in Kyoto Encyclopedia of Genes and Genomes (KEGG) of huPBMC-AIA RNA-seq. t test was conducted for statistical significance. Error bars represent mean ± SEM, ****, p < 0.0001; ***, p < 0.001; **, p < 0.01; *, p < 0.05

Back to article page