Fig. 2

A The schematic Illustration of animal studies. B Human immune system multilineage development: FACS analysis of the human CD45 + cell fraction in the peripheral blood of humanized mice − 2, -1 and 0 weeks after humanization. C Engraftment efficiency (%graft) between the different groups. %graft was calculated as the proportion of human CD45+cells in the total CD45+cell population (human and mouse) in peripheral blood. D In-vivo depletion of endogenous Myeloid-derived suppressor cells (MDSCs) with Gr-1 antibody, and the proportion of MDSCs (CD11b and Gr-1 positive) decreased after intervention. E The photographs images of ankles between huPBMC-AIA and control group (0 day, 3 days, 7days). F Average paw thickness in huPBMC-AIA and control group after different treatments, summary of 3 independent replicate experiments (n = 15). G Top 5 enrichment analysis of biological processes in Kyoto Encyclopedia of Genes and Genomes (KEGG) of huPBMC-AIA RNA-seq. t test was conducted for statistical significance. Error bars represent mean ± SEM, ****, p < 0.0001; ***, p < 0.001; **, p < 0.01; *, p < 0.05