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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model

Fig. 3

A Representative immunofluorescence staining of paw tissues showing the expression of CD3 (red) and ICOS (green) at day3 (scale bar: 100 μm). White arrows indicate cells that colocalize. B Pie Chart and FACS analysis of ICOS expression on CD4 and CD8 T cells in BM of huPBMC-AIA (n = 6) and control group (n = 4) at day7. C tSNE plot and FACS analysis of ICOS expression on CD4 and CD8 T cells in paw of huPBMC-AIA (n = 6) and control group(n = 4) at day7. D Correlation between paw thickness measurements and percentage of human CD45+CD4+ICOS+ cells at the day7 time point. E Principal component analysis identifies major mediators distinguishing huPBMC-AIA mice from control mice. Each dot represents an individual mouse(left). Each line represents key drivers of the delineation. All values represent the mean ± SEM unless otherwise specified. t test was conducted for statistical significance. ****, p < 0.0001; ***, p < 0.001; **, p < 0.01; *, p < 0.05; ns p > 0.05

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Journal of Translational Medicine

ISSN: 1479-5876

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