Fig. 1

Relative EEG power increased and ADC value decreased during the initial phase of SE. A Schematic of experiment. B Representative EEG tracings in mice treated with pilocarpine. C Representative time–frequency power distribution diagram pre- and post-onset of SE. The gray rectangles represent the initial stage of SE. D–I Changes in relative power of various frequency bands pre- and post-onset of SE. The gray rectangle represents the initial stage of SE. n = 5. J Schematic of experiment. K Representative ADC images reconstructed after DWI scans. The ROIs indicate the calculation regions for bilateral cortical ADC values. L Quantification of mean ADC values of the bilateral cortex. n = 5 per group. M Quantification of cortical water content. n = 5 per group. Data are presented as mean ± SEM, unpaired t-test. *P < 0.05, ***P < 0.001