Fig. 2

CSF is an important source of cerebral edema during the initial stage of SE. A Schematic of experiment. B Representative images of visualized NaFl leakage. Scale bar = 2 mm. C Quantification of the mean fluorescence intensity of NaFl in brain sections. n = 5 per group. D Quantification of the proportion of NaFl leakage into brain tissue. n = 6 per group. E Schematic of experiment. F Representative images of fluorescent tracer transport and distribution within 30 min after CM injection. Scale bar = 2 mm. The dashed area represents the ROIs included in the quantification. G Influx area of fluorescent tracer during the 30 min after CM injection, quantified from the ROIs in (F). n = 5 per group. H Quantification of the influx area of fluorescent tracer at 30 min. n = 5 per group. I Representative images of fluorescent tracer coverage in brain sections. Scale bar = 2 mm. J Quantification of the fluorescent tracer coverage. n = 5 per group. Data are presented as mean ± SEM, unpaired t-test. *P < 0.05, ****P < 0.0001, ns = not significant