Fig. 5

PBM depletion attenuates cerebral edema following SE. A Schematic of experiment. B Representative images of fluorescent tracer distribution within 30 min after CM injection. Scale bar = 2 mm. The dashed area represents the ROIs in the bilateral cortex included in the quantification. C Influx area of fluorescent tracer during the 30 min after CM injection, quantified from the ROIs in (B). n = 5 per group. D Quantification of the influx area of fluorescent tracer at 30 min. n = 5 per group. E Representative images of fluorescent tracer coverage in brain sections. Scale bar = 2 mm. F Quantification of the fluorescent tracer coverage. n = 5 per group. G Quantification of cortical water content. n = 5 per group. H Schematic of experiment. I Representative ADC images reconstructed after DWI scans. J Quantification of mean ADC values of the bilateral cortex. n = 5 per group. K Representative images of IgG leakage in brain parenchyma. Scale bar = 2 mm. L Quantitative analysis of IgG leakage. n = 5 per group. M Quantification of cortical water content. n = 5 per group. Data are presented as mean ± SEM, unpaired t-test. *P < 0.05, **P < 0.01, ***P < 0.001