Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches

Table 2 Regulation of CD8 + T-cell function by miRNAs and lncRNAs in HCC

miRNA/lncRNA	Target gene/pathway	Effect on CD8 + T-cells	References
has-miR-23b-3p, lncRNA AC104820.2	T-cell-related genes (CD5L, EOMES, CST7)	Upregulation	[32]
has-miR-23a-3p, lncRNA AC000476.1	CD8 + T-cell-related genes	Upregulation	[32]
circZMIZ1	miR-15a-5p/KCNJ2 axis	Suppresses apoptosis and increases cytotoxicity	[33]
NEAT1	miR-155/Tim-3 pathway	Reduces apoptosis, enhances cytolytic activity	[34]
CircCCAR1	miR-127-5p/WTAP	Promotes dysfunction by stabilizing PD-1	[35]
miR-429	PD-L1	Promotes infiltration, prevents immunosuppressive microenvironment	[36]
miR-206	Klf4/M1 polarization	Recruits CTLs, inhibits cell development	[37]

ISSN: 1479-5876