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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis

Fig. 3

Mfsd2a inhibits CRC cell migration, invasion, EMT, and CRLM formation. (A,B) Wound healing assays and Transwell assays were used to evaluate the effects of Mfsd2a overexpression on RKO and CT26 cell migration and invasion. (C,D) Immunofluorescence and Western blot analyses were performed to assess the expression of EMT-related proteins. (E) Representative bioluminescence images from the CRLM model. (F) Representative images of CRLM formation and H&E staining of liver metastasis sections in the CRLM model with oeMfsd2a CT26 cells, including statistical results for liver weight and percentage of liver metastatic lesions. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)

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