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Table 1 Summary ligand-EPOR binding properties including data for association rate constants, dissociation rate constants, equilibrium dissociation constant and EPOR residence time

From: Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction

ESA

Association rate constant Ka (M−1 s−1)

Dissociation rate constant Kd (s−1)

KD (pM)

Residence time (min)

EPO

5.62 × 106

1.60 × 10–4

28.5

72

Pegmolesatide

1.37 × 105

3.84 × 10–5

280

301

Peptide dimer

2.48 × 106

1.71 × 10–4

69.1

68

rHuEPO (ESPO 3000)

2.63 × 106

2.48 × 10–4

94.2

47

rHuEPO (YIBIAO)

1.16 × 106

2.63 × 10–4

227

44

Darbepoetin

1.44 × 106

3.26 × 10–4

226

35