ESA | Association rate constant Ka (M−1 s−1) | Dissociation rate constant Kd (s−1) | KD (pM) | Residence time (min) |
---|---|---|---|---|
EPO | 5.62 × 106 | 1.60 × 10–4 | 28.5 | 72 |
Pegmolesatide | 1.37 × 105 | 3.84 × 10–5 | 280 | 301 |
Peptide dimer | 2.48 × 106 | 1.71 × 10–4 | 69.1 | 68 |
rHuEPO (ESPO 3000) | 2.63 × 106 | 2.48 × 10–4 | 94.2 | 47 |
rHuEPO (YIBIAO) | 1.16 × 106 | 2.63 × 10–4 | 227 | 44 |
Darbepoetin | 1.44 × 106 | 3.26 × 10–4 | 226 | 35 |