Fig. 4

CAG is characterized by reduced phagocytosis and an activated mast cell phenotype. (A) UMAP plot of myeloid cells, color-coded by cell type. (B) Bubble plot showing significantly enriched pathways of myeloid cells in CAG and control samples. (C) Feature plot color-coded for expression (gray to red) of marker genes for the clusters as indicated. (D) Feature plots of representative DEGs between CAG and control samples. (E) Proportion of FPR1-, MSR1-, CD36-, and MRC1-expressing macrophages in CAG and control samples. (F) UMAP plot of mast cells. (G) Bar plots showing pathways enriched in mast cells in the CAG group. (H) Violin plots showing the differences in the expression levels of mast cell activation genes between CAG and control samples. P values were calculated via the two-sided Wilcoxon test.