Fig. 2

An analysis of transcriptional profiles and KEGG pathway enrichments in COVID-19 vs. healthy PBMNCs along with TMPRSS2high versus TMPRSS2low MCF-7 and EA.Hy926 cells were conducted using RNA sequencing. A: A Volcano plot depicts the differentially expressed genes (DEGs) between COVID-19 and healthy blood samples (COVID19db). Genes that are significantly downregulated are indicated in dark blue, while significantly upregulated genes are shown in red and non-significantly regulated genes are represented in grey. B: The top 10 enriched KEGG pathways from the upregulated genes between COVID-19 and healthy blood samples are presented. C, D: The top 20 enriched KEGG terms derived from the upregulated genes of TMPRSS2high versus TMPRSS2low MCF-7 (C) and EA.Hy926 (D) cells are displayed. The enriched GO terms found in both TMPRSS2high and COVID-19 are highlighted with green circles. E: Correlation plots illustrate the commonly upregulated genes in the two most enriched KEGG pathways concerning TMPRSS2 expression from blood samples of COVID-19 patients (COVID19db). The gene expressions of OAS1, STAT1 and IRF7 are exemplified here