Fig. 3

In silico gene perturbation analysis. (A) Human Embryonic Stem Cells (EBs): Individual and combined perturbations of OTX2 and POU5F1, and multi-gene co-perturbations. The left matrix plot shows the expression changes of key genes at different time points. (B) Zebrafish Embryos (ZE): Up-regulation of GSC, NTD5, and SOX32