Fig. 6

Exosomal miR-188-3p in plasma of CRC patients correlates with liver metastasis. a. The expression levels of miR-188-3p were assessed in CRC patients with stage I-II and stage III-IV tumors using qRT-PCR. b, c. Plasma exosomes were additionally identified through electron microscopy (b) and Nanosight particle tracking analysis (c). d. qRT-PCR assays were employed to assess the expression of miR-188-3p in plasma exosomes obtained from CRC patients without liver metastasis (None LM) and those with liver metastasis (LM). e, f. Kaplan-Meier survival analysis and log-rank tests were employed to assess the correlations between miR-188-3p in plasma exosomes and DFS (e) and OS (f) in CRC patients. (***p < 0.001)