Fig. 2

High expression of circPRKCA in ESCC tissues and its impact on the prognosis of ESCC patients. A Representative images of circPRKCA expression analyzed using FISH on tissue microarrays. B CircPRKCA expression ratio in 108 ESCC tissues compared to 64 adjacent tissues. C Distributions of clinical stages were analyzed according to circPRKCA expression level in 108 ESCC tissues. D Rates of lymph node metastasis were analyzed based on the expression levels of circPRKCA in 108 ESCC tissues. E Kaplan–Meier survival analysis shows the overall survival rate based on circPRKCA expression. F A multivariate Cox regression analysis was conducted to evaluate the prognostic factors associated with ESCC patients. * p < 0.05, ** p < 0.01, *** p < 0.001