Fig. 1
From: Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMB
Expression of GPNMB in human malignant mesothelioma tissues. A TCGA analysis in 85 MPM patients for mRNA levels of Gpnmb, CD44 and IL-33 genes, and B survival of patients classified according to high/low expression of the GPNMB and CD44 genes. P value by log-rank test. C Plasmatic levels of soluble GPNMB measured by ELISA in 72 patients with pathologically confirmed diagnosis of MPM and in 86 healthy donors. Statistical analysis Unpaired t-test (< 0.0001). D Representative images of immunohistochemistry of GPNMB and E of CD206 in two distinct cases of human MPM. F heat map quantification in 28 MPM patients. G RNAscope experiment in two distinct cases of human MPM: single staining of Gpnmb RNA (purple) or CD68 (brown); double staining (H) is shown for each corresponding sample