Fig. 5
From: Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMB
Blockade of the CD44 receptor reduces tumor growth in vivo. Mice were treated with a neutralizing anti-CD44 mAb or an irrelevant Ab (10 mg/kg) at days 8, 11, 14, 17 and 20 post AB22 cell injection. A Tumor progression of AB22 cells in control and anti-CD44 treated animals (mean values of 5 mice, expressed as average radiance) and, B in each single mouse. C Results expressed as fold increase (F.I.) relative to the previous quantification (mean values of 5 mice, and D in each single mouse. E In vivo imaging by IVIS. F Immunohistochemistry of tumor nodules stained for the quantification of the leukocyte infiltrate and for the expression of GPNMB. Statistical analysis Mixed effect model for A–D; Student t-test Welch’s correction for F (*: < 0.05; ***: (*: < 0.01))