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Table 4 Overview for optimal cut-off values for the ratios based on Youden-Index and corresponding AUC, sensitivity and specificity values

From: Immunomarker profiling in human chronic wound swabs reveals IL-1 beta/IL-1RA and CXCL8/CXCL10 ratios as potential biomarkers for wound healing, infection status and regenerative stage

  

Ratio Cut-Off

AUC

Sensitivity (in %)

Specificity (in %)

Youden-index

HEAL vs. NON-HEAL

MMP- 9/TIMP- 1

 > 0.594

0.6124

51.56

71.74

0.23

IL- 1 beta/IL- 1RA

 > 0.008

0.6837

85.94

44.44

0.30

CXCL- 8/CXCL- 10

 > 139.8

0.6530

53.85

74.47

0.28

INFE vs

NON-INFE

MMP- 9/TIMP- 1

 < 1.017

0.5058

81.82

38.46

0.20

IL- 1 beta/IL- 1RA

 < 0.017

0.6186

41.67

84.62

0.26

CXCL- 8/CXCL- 10

 < 86.36

0.7669

51.55

100.00

0.52

INFE vs. INFLA

MMP- 9/TIMP- 1

 < 0.336

0.5760

46.15

73.17

0.19

IL- 1 beta/IL- 1RA

 > 0.017

0.5558

84.62

35.00

0.20

CXCL- 8/CXCL- 10

 > 77.58

0.7298

100.00

51.22

0.51

  1. AUC area under the curve, HEAL healing wound, NON-HEAL non-healing wound, INFE infected wound, NON-INFE non-infected wound, INFLA inflamed wound