Fig. 8
From: Transcriptome-scale analysis of functional alternative back-splicing events in colorectal cancer
Different functional roles of circXPO1-1 and circXPO1-2 in HCC cell lines. a CCK-8 assay and (b) Colony formation assay in SW620 and LoVo cells detecting cell proliferation transfected with control, OE-circXPO1-1, and OE-circXPO1-2 vectors. c, d Transwell assays reveal cell migration and invasion in SW620 and LoVo cells transfected with control, OE-circXPO1-1, and OE-circXPO1-2 vectors. e Tumor size and tumor weight (f) were accessed for each derived xenograft tumor. Xenograft tumor models were established using LoVo cells stably transfected with control, OE-circXPO1-1, and OE-circXPO1-2 vectors. g Volcano plot of differentially expressed genes in LoVo cells stably transfected with control and OE-circXPO1-2 vectors. h Relative mRNA expression levels of differentially expressed genes detected by qRT-PCR in control and OE-circXPO1-2 LoVo cells. ** P-value < 0·01, *** P-value < 0·001. i Cancer hallmark enrichment analysis of differentially expressed genes in control and OE-circXPO1-2 LoVo cells. j GSEA plots of differentially expressed gene sets involved in regulation of carcinogenesis