Fig. 2

Characterization of RiboSis-related genes in LUAD scRNA-seq data. (A) Following dimensionality reduction and clustering, cells from 9 LUAD samples were grouped into 24 cell clusters. (B) Cell annotation yielded 9 cell subtypes. (C) Bubble plot displaying typical marker genes for the 9 cell subtypes. (D) Expression distribution of 9 typical marker genes across samples. (E) Violin plots comparing RiboSis activity scores of the 9 cell subtypes. B cells and T cells exhibit higher RiboSis activity scores, while endothelial cells, plasma cells, and epithelial cells show lower RiboSis activity scores. (F) UMAP plot illustrating the cell distribution of high and low RiboSis-AUC groups. (G) Network plot comparing cell communication quantity and intensity between high and low RiboSis-AUC groups. (H) Contrasting incoming and outgoing interaction strengths among different cell subtypes between high and low RiboSis-AUC groups. (I, J) Comparison of signaling pathway strengths between high and low RiboSis-AUC groups. (K) Upregulated and downregulated ligand-receptor pairs in different cell subtypes of high and low RiboSis-AUC groups