Table 1 Platelet-derived EVs main cargo and roles
Platelet-derived EVs | |
|---|---|
Cargo | Role |
Caspase 3 and Rho-kinase | Proapoptotic |
Tissue factor, phosphatidylserine | Procoagulant, oxidative stress |
NADPH oxidase, disulfide isomerase, NOS | Downregulate cardioprotective miR223 |
miR-1915-3p, miR-4,507, miR-3,656 | Reduced in early-stage AMI |
miR-122-5p | Correlates with ACS severity |
miR-126-3p, miR-199-5p | Inverse correlation with MACE |
miR-223, miR-339 and miR-21 | Inhibit PDGFRβ (biomarker of atherosclerosis) |
CXCL7 and CXCL10 | More expressed in T2DM |