Fig. 3

Comparison of baseline TRI-001 transcriptional landscape to selected macrophage subtypes [1]. Principal component analysis of the top 500 genes by sample variance of VST-transformed expression values. PC1 and PC2 are shown on the x- and y-axis, respectively. Groups are indicated with colors and the sources with symbols (A). Pairwise Pearson’s correlations on top 500 most variable genes. Samples are clustered using hierarchical clustering based on Pearson’s correlation coefficients. Groups and sources are annotated with colors/symbols on the top. Pearson correlations are visualized as a color scale from blue (low) to yellow (mid) to red (high) (B). Hierarchically clustered heatmap showing normalized expression of 25 pre-selected marker genes. Samples are clustered using hierarchical clustering based on VST-transformed expression values. Rows show genes and columns show samples. Normalized expressions are visualized as a color scale from yellow (low) to brown (high) (C)