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Computational modelling and Epidemiology

Section edited by Michael N. Liebman

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

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  1. Screening is effective in reducing the disease burden of colorectal cancer, with participation and coverage rates being key determinants of its effectiveness. This systematic review aims to provide a comprehen...

    Authors: Yuqing Chen, Yuelun Zhang, Yike Yan, Jingjing Han, Li Zhang, Xinran Cheng, Bin Lu, Na Li, Chenyu Luo, Yueyang Zhou, Kai Song, Motoki Iwasaki, Min Dai, Dong Wu and Hongda Chen
    Citation: Journal of Translational Medicine 2025 23:811
  2. Quantitative calculation models for the ratio of daily area under the concentration–time curve (AUC24) to the minimum inhibitory concentration (MIC) (i.e., AUC24/MIC) and the amount of time that concentration sta...

    Authors: Xiangqing Song
    Citation: Journal of Translational Medicine 2025 23:806
  3. In the era of risk-based prostate cancer (PCa) screening, overcoming the limitations of prostate-specific antigen (PSA) testing and stratifying men by individual risk is crucial. Our study aims to integrate an...

    Authors: Caterina Peraldo-Neia, Paola Ostano, Melissa Savioli, Maurizia Mello-Grand, Ilaria Gregnanin, Francesca Guana, Francesca Crivelli, Francesco Montagnani, Michele Dei-Cas, Rita Paroni, Antonella Sinopoli, Francesco Ferranti, Nicolò Testino, Marco Oderda, Andrea Zitella, Chiara Fiameni…
    Citation: Journal of Translational Medicine 2025 23:790
  4. Smoking is a well-established risk factor for bladder cancer; however, the molecular mechanisms underlying this association remain unclear. This study aimed to elucidate the link between smoking and bladder ca...

    Authors: Feixiang Wu, Shasha Wu, Yu Huang, Xiao Xiao, Haitao Yu, Xuesong Bai, Chunlin Zhang, Zhenwei Feng, Li Li, Yuhua Mei, Xinyuan Li and Xin Gou
    Citation: Journal of Translational Medicine 2025 23:785
  5. Drug repositioning offers a promising avenue for accelerating drug development and reducing costs. Recently, computational repositioning approaches have gained attraction for identifying potential drug-disease...

    Authors: Congzhou Chen, Yaozheng Zhou, Yinghong Li, Jin Xu, Demin Li and Lingfeng Wang
    Citation: Journal of Translational Medicine 2025 23:753
  6. Despite advances in precision medicine, the translation of genetic and genomic technologies into routine practice is hampered by a heterogeneous and limited evidence base and the absence of standardized evalua...

    Authors: Antonio Sciurti, Giuseppe Migliara, Valentina Baccolini, Maria Roberta De Blasiis, Giuseppe Di Lorenzo, Ilaria Mussetto, Arianna Anniballo, Jessica Iera, Claudia Isonne, Anna Ewa Kaminska, Francesco Pierri, Andrea Pistollato, Marianna Riccio, Annalisa Rosso, Leonardo Maria Siena, Valentina Soccodato…
    Citation: Journal of Translational Medicine 2025 23:749
  7. Smoking represents the largest preventable risk factor for human health, yet previous studies have failed to establish conclusive evidence regarding the causal relationship between smoking and neurodegenerativ...

    Authors: Chaochao Chen, Shouqiang Zhu, Zhiying Zheng, Xiahao Ding, Weihai Shi, Tianjiao Xia and Xiaoping Gu
    Citation: Journal of Translational Medicine 2025 23:743
  8. The role of microglial activation by α-synuclein in Alzheimer’s disease (AD) remains unclear. This study aimed to evaluate the role of soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in regul...

    Authors: Yong-Chang Wang, Liang-Yu Huang, Yan-Fu, Shi-Yin Xiong, Zuo-Teng Wang, Chen-Chen Tan and Lan Tan
    Citation: Journal of Translational Medicine 2025 23:731
  9. Understanding interindividual variability in medication dosing is central to precision medicine. Despite significant pharmacogenomic (PGx) insights into key biological pathways influencing drug response, the p...

    Authors: Silva Kasela, Laura Birgit Luitva, Kristi Krebs, Märt Möls, Lili Milani and Maris Alver
    Citation: Journal of Translational Medicine 2025 23:727
  10. Breast cancer (BC) is a critical cause of cancer-related death globally. The heterogeneity of BC subtypes poses challenges in understanding molecular mechanisms, early diagnosis, and disease management. Recent...

    Authors: Mahmoud M. Omran, Mohamed Emam, Mariam Gamaleldin, Asmaa M. Abushady, Mustafa A. Elattar and Mohamed El-Hadidi
    Citation: Journal of Translational Medicine 2025 23:709
  11. Many biochemical markers are involved in cardiovascular (CV) prognosis in the hypertensive population, but most findings are derived from a single-exposure setting, and their interaction and potential pathways...

    Authors: Simiao Tian, Zhen Li, Yanhong Bi, Xiaoyu Che, Ao Feng and Yiou Wang
    Citation: Journal of Translational Medicine 2025 23:690
  12. Increasing evidence suggests that the gut microbiome may play an important role in the development of colorectal tumors. Antibiotic use can affect the gut microbiome and may increase the risks of benign and ma...

    Authors: Yi-Cheng Liu, Xiang-Yi Tang, Ji-Xuan Lang, Yue Qiu, Ye Chen, Xin-Yun Li, Yu Cao and Chun-Dong Zhang
    Citation: Journal of Translational Medicine 2025 23:682
  13. Artificial Intelligence (AI) offers a revolutionary approach to improve decision-making in medicine through the use of advanced computational tools. Its ability to analyze large and complex datasets enables a ...

    Authors: Shiva Arjmandmazidi, Hamid Reza Heidari, Tohid Ghasemnejad, Zeinab Mori, Leila Molavi, Amir Meraji, Shadi Kaghazchi, Elnaz Mehdizadeh Aghdam and Soheila Montazersaheb
    Citation: Journal of Translational Medicine 2025 23:678
  14. Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by sustained elevation of pulmonary arterial pressure, endothelial cell dysfunction, and right ventricular failure. A wide ...

    Authors: Elizabeth Singh and Malik Bisserier
    Citation: Journal of Translational Medicine 2025 23:665
  15. Body mass index z-score (BMI-Z) and waist-to-height ratio (WHtR) are widely used to assess children’s nutrition and metabolic status. Neck-to-height ratio (NHtR), triglyceride-glucose index (TyG), visceral adi...

    Authors: Wu Yan, Luting Peng, Yanan Shi, Mengyao Cao, Qingqing Zheng, Shenghu Gao, Qianqi Liu and Xiaonan Li
    Citation: Journal of Translational Medicine 2025 23:664
  16. Findings of previous observational investigations about the relation between circulating 25-hydroxyvitamin D (25(OH)D) and hypertension (HTN) in children and adolescents were inconsistent. This systematic revi...

    Authors: Elahe Mokhtari, Zahra Moradmand, Parisa Rouhani and Parvane Saneei
    Citation: Journal of Translational Medicine 2025 23:625
  17. Parkinson's disease (PD), the second most common neurodegenerative disease with notable clinical heterogeneity, has Parkinson disease dementia (PDD) that severely impacts patients' quality of life. As no effec...

    Authors: Tayier Tuersong, Yu Xuan Yong, Yan Chen, Pei Shan Li, Samire Shataer, Munire Shataer, Liang Ying Ma and Xin Ling Yang
    Citation: Journal of Translational Medicine 2025 23:535
  18. The brain imaging subtypes of schizophrenia have been widely investigated using data-driven approaches. However, the heterogeneity of SZ in multiple biological data is largely unknown.

    Authors: Yuran Wang, Shixuan Feng, Yuanyuan Huang, Runlin Peng, Liqin Liang, Wei Wang, Minxin Guo, Baoyuan Zhu, Heng Zhang, Jianhao Liao, Jing Zhou, Hehua Li, Xiaobo Li, Yuping Ning, Fengchun Wu and Kai Wu
    Citation: Journal of Translational Medicine 2025 23:505
  19. Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are synthetic chemicals known for their widespread use and environmental persistence...

    Authors: Yanggang Hong, Deqi Wang, Zeyu Liu, Yuxin Chen, Yi Wang and Jiajun Li
    Citation: Journal of Translational Medicine 2025 23:504
  20. Emerging evidence implicates environmental contaminants such as cadmium (Cd) as modifiable risk factors for anxiety. Despite growing recognition of heavy metal toxicity in neuropsychiatric disorders, the molec...

    Authors: Sheng Wan, Yong Yang, Qihan Zhao, Zelong Xing, Jie Li, Hao Gao, Yinghui Yin, Zhenzhong Liu, Qiwen Chen, Maoqin Tian, Xinxin Shi, Ziyue Ji and Shaoxin Huang
    Citation: Journal of Translational Medicine 2025 23:499
  21. Modifiable factors affect cancer’s survival but literature did not differentiate prior to versus after cancer diagnosis. It is essential to provide references for the intervention prioritized at different stages.

    Authors: Xiong Chen, Dongxi Zhu, Chenchen Li, Yi Lin, Lin Lv, Feiling Ai, Zhijian Chen, Runnan Shen, Xuwen Shen, Guochang You, Zhige Jiang, Wenlong Zhong and Tianxin Lin
    Citation: Journal of Translational Medicine 2025 23:486

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2025 23:563

  22. Early-life smoking is linked to biological aging and chronic diseases, yet its specific relationship with cardiovascular disease (CVD) risk and the role of DNA methylation biomarkers of aging as potential medi...

    Authors: Chang Sheng, Rui Zhou, Hongcai Wang, Guoqiang Lin, Zhou Cai and Wei Wang
    Citation: Journal of Translational Medicine 2025 23:484
  23. Metabolic Associated Steatotic Liver Disease (MASLD), encompassing conditions simple liver steatosis (MAFL) and metabolic associated steatohepatitis (MASH), is the most prevalent chronic liver disease. Current...

    Authors: Weiliang Zhang, Weirong Lu, Yaqi Jiao, Tianhao Li, Haining Wang and Chunhua Wan
    Citation: Journal of Translational Medicine 2025 23:472
  24. Epidemiological studies have found an association between air pollution and cardiovascular and cerebrovascular diseases (CACD) and its subtypes. However, there is a lack of individual-level data to explore the...

    Authors: Fei Lin, Guohua Li, Yongbin Wang, Pingshuan Dong, Kan Yang, Hui Liu, Na Xie, Jingyu Liu, Hengwen Chen, Xiaomei Liu, Huan Li, Xuefang Li, Dongxu Li, Siyu Sun, Xiulong Wang, Yujing Sun…
    Citation: Journal of Translational Medicine 2025 23:469
  25. Peripheral arterial disease (PAD) is a common cardiovascular disease that it is an important reason for the decline of patients’ quality of life and the increase of family economic burden. To systematically ev...

    Authors: Congzhi Yan, Jiahao Chen, Xinbing Xu, Hua Wei and Jinjiao Li
    Citation: Journal of Translational Medicine 2025 23:463
  26. Systems biology is a holistic approach to biological sciences that combines experimental and computational strategies, aimed at integrating information from different scales of biological processes to unravel ...

    Authors: Aurelia Morabito, Giulia De Simone, Roberta Pastorelli, Laura Brunelli and Manuela Ferrario
    Citation: Journal of Translational Medicine 2025 23:425
  27. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern that necessitates early screening and timely intervention to improve prognosis. The current diagnostic protocols for ...

    Authors: Gangfeng Zhu, Yipeng Song, Zenghong Lu, Qiang Yi, Rui Xu, Yi Xie, Shi Geng, Na Yang, Liangjian Zheng, Xiaofei Feng, Rui Zhu, Xiangcai Wang, Li Huang and Yi Xiang
    Citation: Journal of Translational Medicine 2025 23:381
  28. Esophageal cancer (EC) presents a significant public health challenge globally, particularly in regions with high alcohol consumption. Its etiology is multifactorial, involving both genetic predispositions and...

    Authors: Oswald Ndi Nfor, Pei-Ming Huang, Ming-Fang Wu, Ke-Cheng Chen, Ying-Hsiang Chou, Mong-Wei Lin, Ji-Han Zhong, Shuenn-Wen Kuo, Yu-Kwang Lee, Chih-Hung Hsu, Jang-Ming Lee and Yung-Po Liaw
    Citation: Journal of Translational Medicine 2025 23:379
  29. Mind-body therapies are a group of treatments based on the theory of mind-body medicine, which are effective for a wide range of illnesses. However, there are no bibliometric papers that have examined the topi...

    Authors: Yunxiao Zhang, Wenwen Li, Sai Xu, Shudi Li, Zhen Hai Sun, Menghe Zhang, Yaoyao Zuo and Shouqiang Chen
    Citation: Journal of Translational Medicine 2025 23:365
  30. Understanding the evolving patterns of cardiovascular disease (CVD) burden attributable to ambient particulate matter pollution (APMP) is essential. Furthermore, research on the underlying mechanisms has mostl...

    Authors: Haoxian Tang, Jingtao Huang, Hanyuan Lin, Xuan Zhang, Qinglong Yang, Nan Luo, Mengyue Lin, Cuihong Tian, Shiwan Wu, Jianan Hong, Jiasheng Wen, Liwen Jiang, Pan Chen, Xiaojing Chen, Junshuang Tang, Youti Zhang…
    Citation: Journal of Translational Medicine 2025 23:359
  31. The number of cancer survivors has steadily increased due to earlier detection and more effective therapies. Do all types of cancer survivors have an increased risk of developing subsequent cancers compared wi...

    Authors: Yubo Wang, Yining Jiang, Yang Bai and Haiyang Xu
    Citation: Journal of Translational Medicine 2025 23:355
  32. As global cancer incidence and mortality rise, digital twin technology in precision medicine offers new opportunities for cancer treatment.

    Authors: Shiying Shen, Wenhao Qi, Xin Liu, Jianwen Zeng, Sixie Li, Xiaohong Zhu, Chaoqun Dong, Bin Wang, Yankai Shi, Jiani Yao, Bingsheng Wang, Louxia Jing, Shihua Cao and Guanmian Liang
    Citation: Journal of Translational Medicine 2025 23:348
  33. Lung cancer, one of the leading causes of cancer-related morbidity and mortality worldwide, is strongly associated with smoking as its primary carcinogenic factor. However, despite the strong link between smok...

    Authors: Can Ouyang, Xiaopeng Yu, Huazhong Wang and Puhua Zeng
    Citation: Journal of Translational Medicine 2025 23:330
  34. Advancements in artificial intelligence (AI) and machine learning (ML) have revolutionized the medical field and transformed translational medicine. These technologies enable more accurate disease trajectory m...

    Authors: Laith Abualigah, Saleh Ali Alomari, Mohammad H. Almomani, Raed Abu Zitar, Kashif Saleem, Hazem Migdady, Vaclav Snasel, Aseel Smerat and Absalom E. Ezugwu
    Citation: Journal of Translational Medicine 2025 23:302
  35. Postpartum depression (PPD) is a significant public health issue. This study aimed to develop and validate machine learning (ML) models using biopsychosocial predictors to predict the risk of PPD for perinatal...

    Authors: Weijing Qi, Yongjian Wang, Yipeng Wang, Sha Huang, Cong Li, Haoyu Jin, Jinfan Zuo, Xuefei Cui, Ziqi Wei, Qing Guo and Jie Hu
    Citation: Journal of Translational Medicine 2025 23:291
  36. Studies have indicated that COVID-19 infection may accelerate the aging process in organisms. However, it remains unknown whether contracting COVID-19 affects life expectancy. Furthermore, the underlying biolo...

    Authors: Shizheng Qiu, Jianhua Liu, Jiahe Guo, Zhishuai Zhang, Yu Guo and Yang Hu
    Citation: Journal of Translational Medicine 2025 23:283
  37. Alzheimer’s disease (AD) is the main cause of dementia with few effective therapies. We aimed to identify potential plasma biomarkers or drug targets for AD by investigating the causal association between plas...

    Authors: Hui Zhan, Davis Cammann, Jeffrey L. Cummings, Xianjun Dong and Jingchun Chen
    Citation: Journal of Translational Medicine 2025 23:278
  38. Osteonecrosis (ON) is a debilitating orthopedic condition characterized by bone cell death due to impaired blood supply, leading to structural changes and disability. Osteoporosis (OP), a systemic skeletal dis...

    Authors: Chao Zhang, Hao Yu, Yulin Miao and Biaofang Wei
    Citation: Journal of Translational Medicine 2025 23:226
  39. Given the close relationship between lipids and gestational diabetes mellitus(GDM), the present study sought to examine the association between the triglyceride high-density cholesterol-glucose body index(TyHG...

    Authors: Ziyi Xu, Changhui Li, Nanzhu Wang and Guojiao Song
    Citation: Journal of Translational Medicine 2025 23:190
  40. The aim of this study was to explore the systemic inflammation response in relation to mortality in Helicobacter pylori (H. pylori) infection, and whether this relationship was mediated by accelerated biological ...

    Authors: Jiayu Qiu, Hui Fang, Dingwei Liu, Qirui Lai, Jinliang Xie, Youhua Wang, Sihai Chen and Yong Xie
    Citation: Journal of Translational Medicine 2025 23:174
  41. Methylglyoxal (MGO)-induced cell death in vascular endothelial cells (VECs) plays a critical role in the progression of diabetic vascular complications (DVCs). Previous studies have shown that MGO can induce i...

    Authors: Ruqiang Yuan, Hu Xu, Mingqi Wang, Lina Guo, Yang Yao, Xiaoru Zhang and Xiuli Wang
    Citation: Journal of Translational Medicine 2025 23:170
  42. Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and an...

    Authors: Beiqin Liu, Shuyue Wang, Hong Ma, Yulin Deng, Jichen Du, Yimeng Zhao and Yu Chen
    Citation: Journal of Translational Medicine 2025 23:132
  43. To develop a machine learning-based prediction model using clinical data from the first 24 h of ICU admission to enable rapid screening and early intervention for sepsis patients.

    Authors: Songchang Shi, Lihui Zhang, Shujuan Zhang, Jinyang Shi, Donghuang Hong, Siqi Wu, Xiaobin Pan and Wei Lin
    Citation: Journal of Translational Medicine 2025 23:97
  44. Risk-based breast cancer screening offers a more targeted and potentially cost-effective approach in cancer detection compared to age-based screening. This study aims to understand women’s preferences and will...

    Authors: Yi Wang, Peh Joo Ho, Langming Mou and Jingmei Li
    Citation: Journal of Translational Medicine 2025 23:96
  45. Despite the use of Next-Generation Sequencing (NGS) as the gold standard for the diagnosis of rare diseases, its clinical implementation has been challenging, limiting the cost-effectiveness of NGS and the und...

    Authors: Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego and Guillermo Antiñolo
    Citation: Journal of Translational Medicine 2025 23:86

Annual Journal Metrics

  • Citation Impact 
    Journal Impact Factor: 7.5 (2024)   
    5-year Journal Impact Factor: 7.0 (2024)    
    Source Normalized Impact per Paper (SNIP): 1.321 (2024)    
    SCImago Journal Rank (SJR): 1.997 (2024)

    Speed 
    Submission to first editorial decision (median days): 11
    Submission to acceptance (median days): 99

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