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Network Medicines

Section edited by Wendy Mao and Gianni Monaco

The Network Medicines section is dedicated to the biology-based, integrative approach aimed at understanding the topology of complex disorders and the dynamic interplay of their various components, identifying cascades of causes and effects, listening to cross-talks among cells to suggest novel and more effective therapeutic approaches.

The Network Medicines section aims to build disease atlases with the accuracy matching that of global positioning systems by providing a comprehensive framework of information collected from experimental and clinical data that can identify methods to resolve disease in the most efficient pathway. The section welcomes research that goes beyond descriptive observations and provides compelling recommendations of disruptive therapeutic candidates.

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  1. Cancer originates from dysregulated cell proliferation driven by driver gene mutations. Despite numerous algorithms developed to identify genomic mutational signatures, they often suffer from high computationa...

    Authors: Xiangmei Li, Bingyue Pan, Xilong Zhao, Yinchun Su, Jiyin Lai, Siyuan Li, Yalan He, Jiashuo Wu and Junwei Han
    Citation: Journal of Translational Medicine 2025 23:518
    Content type: Research Published on:

  2. Lung adenocarcinoma (LUAD) presents a considerable danger to human health and has evolved into a major public health concern. Ribosome biogenesis (RiboSis) is a critical process for synthesizing ribosomes, clo...

    Authors: Zipei Song, Yuheng Wang, Miaolin Zhu, Pengpeng Zhang, Zhihua Li, Xin Geng, Xincen Cao, Jianan Zheng, Jianwei Tang and Liang Chen
    Citation: Journal of Translational Medicine 2025 23:503
    Content type: Research Published on:

  4. Patients with small-cell lung cancer (SCLC) have the poor prognosis. Current research suggested that low-dose radiotherapy (LDRT) combined with immunotherapy can enhance the immunogenicity of tumor cells, ther...

    Authors: Guo Lin, Zhuoran Yao, Kai Kang, Ren Luo, Linglu Yi and You Lu
    Citation: Journal of Translational Medicine 2025 23:453
    Content type: Research Published on:

  5. Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignancy with a 5—year survival rate of less than 20%, largely due to its high propensity for metastasis and recurrence. There is an urgent need t...

    Authors: Rong Xiao, Pei Xu, Xiangyuan Li, Feng Shen, Shuangfen Tao, Xiaocen Zhu, Yu Cai, Zhuowei Feng, Zhiyi Liu, Haibo Xiao, Fangbao Ding and Meiling Zhu
    Citation: Journal of Translational Medicine 2025 23:438
    Content type: Research Published on:

  6. Esophageal squamous cell carcinoma (ESCC) is a serious invasive malignancy with an ambiguous etiology. Evidence indicates that circular RNA (circRNA) is significantly involved in the regulatory processes assoc...

    Authors: Lixia Wu, Lina Gu, Yang zheng, Jingjing Liu, Zishuan Wei, Fei Liu, Jiali Li, Lingjiao Meng, Yang Sang, Meixiang Sang, Lianmei Zhao and Baoen Shan
    Citation: Journal of Translational Medicine 2025 23:385
    Content type: Research Published on:

  7. The ZBTB (zinc finger and BTB domain-containing) protein family comprises a significant class of transcription factors that interact with various corepressors and histone/protein-modifying enzymes. This intera...

    Authors: Xiaojiang Tang, Chaowei Deng, Yang Liu, Shengyu Pu, Qi Zheng, Yudong Zhou and Na Hao
    Citation: Journal of Translational Medicine 2025 23:370
    Content type: Research Published on:

  8. Metastasis is the leading cause of mortality for colorectal cancer (CRC). Cancer-derived exosomes are widely recognized as the primary catalysts behind the development of pre-metastasis niche (PMN) in distal s...

    Authors: Tao Li, Taiyuan Li, Yahang Liang, Yuli Yuan, Yang Liu, Yao Yao and Xiong Lei
    Citation: Journal of Translational Medicine 2025 23:369
    Content type: Research Published on:

  9. Recent breakthroughs in tumor immunotherapy have confirmed the capacity of the immune system to fight several cancers. The effective means of treating cancer involves accelerating the death of tumor cells and ...

    Authors: Yibin Lin, Yifu Song, Yaochuan Zhang, Xiaodong Li, Liang Kan and Sheng Han
    Citation: Journal of Translational Medicine 2025 23:341
    Content type: Review Published on:

  10. Gastric cancer (GC) is a highly heterogeneous tumour with high morbidity. Approximately 95% of GC cases are gastric adenocarcinomas, which are further categorized into two predominant subtypes: diffuse gastric...

    Authors: Rongji Xu, Danni He, Rui Sun, Jiaqi Zhou, Mengyu Xin, Qian Liu, Yifan Dai, Houxing Li, Yujie Zhang, Jiatong Li, XinXin Shan, Yuting He, Borui Xu, Qiuyan Guo, Shangwei Ning, Yue Gao…
    Citation: Journal of Translational Medicine 2025 23:308
    Content type: Research Published on:

  11. Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive cancers, with rising incidence and limited responsiveness to immunotherapy due to its highly suppressive tumor microenvironment (TME). Terti...

    Authors: Enkui Zhang, Yongsu Ma, Zonghao Liu, Jixin Zhang, Weikang Liu, Yiran Chen, Guangnian Liu, Xinxin Liu, Fusheng Zhang, Yu Zhu, Yinmo Yang and Xiaodong Tian
    Citation: Journal of Translational Medicine 2025 23:301
    Content type: Research Published on:

  12. Cancer-associated fibroblasts (CAFs), known for facilitating the progression and metastasis of colorectal cancer (CRC), have become a promising therapeutic target. However, the significant heterogeneity of CAF...

    Authors: Yunfei Lu, Yang Chen, Zhenling Wang, Hengyang Shen, Lei Xu, Changzhi Huang, Ying Tong, Yu Shao, Hongqiang Zhang and Zan Fu
    Citation: Journal of Translational Medicine 2025 23:282
    Content type: Research Published on:

  13. Although photothermal therapy (PTT) can induce antitumour immunity, the mechanisms underlying its effects in pancreatic cancer (PC) require further exploration. In this study, the mechanism of action of PTT an...

    Authors: Yanyan Hu, ErPeng Qi, Chao Yun, Xi Li, Fangyi Liu, Zhigang Cheng, Na Guan, Qiong Wang, Huixia Zhao, Wenhua Xiao, Liang Peng, Jingwen Yang and Xiaoling Yu
    Citation: Journal of Translational Medicine 2025 23:271
    Content type: Research Published on:

  14. Single-cell multi-omics technologies, particularly single-cell RNA sequencing (scRNA-seq), have revolutionized our understanding of cellular heterogeneity and development by providing insights into gene expres...

    Authors: Suwen Wei, Yuer Lu, Peng Wang, Qichao Li, Jianwei Shuai, Qi Zhao, Hai Lin and Yuming Peng
    Citation: Journal of Translational Medicine 2025 23:264
    Content type: Research Published on:

  15. Characterizing the variety of cell types in the tumor microenvironment (TME) and their organization into cellular communities is vital for elucidating the biological diversity of cancer and informing therapeut...

    Authors: Lei Xiao, Zhe Shen, Zhaoyu Pan, Yuanzheng Qiu, Donghai Huang, Yong Liu, Chao Liu and Xin Zhang
    Citation: Journal of Translational Medicine 2025 23:254
    Content type: Research Published on:

  16. Myocardial infarction (MI) and subsequent ischaemic cardiomyopathy (ICM) are the primary causes of heart failure. Inter-α trypsin inhibitor heavy chain 5 (ITIH5) is an extracellular matrix (ECM) protein and ha...

    Authors: Yirong Wu, Li Meng, Siyao Zhan, Miaofu Li, Jiamin Huang, Xuechun Chen, Liuying Chen, Xiaofei Gao, Hao Chen, Huimin Chen, Yigang Zhong, Linhao Xu and Yizhou Xu
    Citation: Journal of Translational Medicine 2025 23:224
    Content type: Research Published on:

  17. To identify key cellular changes and molecular events in atrophic mucosa, we aimed to elucidate the molecular mechanisms driving the occurrence of chronic atrophic gastritis (CAG).

    Authors: Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He and Weimin Ye
    Citation: Journal of Translational Medicine 2025 23:159
    Content type: Research Published on:

  18. Prostate Tumor Overexpressed 1 (PTOV1) is overexpressed and associated with malignant phenotypes in various types of tumors. However, the detailed roles of PTOV1 and its underlying mechanism in CRC remain uncl...

    Authors: Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu and Di Wang
    Citation: Journal of Translational Medicine 2025 23:157
    Content type: Research Published on:

  19. The revolutionary CRISPR-Cas9 system leverages a programmable guide RNA (gRNA) and Cas9 proteins to precisely cleave problematic regions within DNA sequences. This groundbreaking technology holds immense poten...

    Authors: Ahtisham Fazeel Abbasi, Muhammad Nabeel Asim and Andreas Dengel
    Citation: Journal of Translational Medicine 2025 23:153
    Content type: Review Published on:

  20. Chromatin accessibility plays a crucial role in mediating transcriptional dysregulation and heterogeneity in Esophageal Squamous Cell Carcinoma (ESCC). Examining the chromatin accessibility of ESCC at single-c...

    Authors: Kaiwen Sheng, Jun Chen, Ruitang Xu, Haoqiang Sun, Ran Liu, Yongjie Wang, Wenwen Xu, Jiao Guo, Miao Zhang, Shuai Liu, Juan Lei, Yawen Sun, Yang Jia and Dianhao Guo
    Citation: Journal of Translational Medicine 2025 23:148
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2025 23:334

  21. This study aims to elucidate the primary signaling communication among papillary craniopharyngioma (PCP) tumor cells.

    Authors: Xiaoyue Zhu, Yanfei Jia, Zicheng Zhao, Xiaoyu Zhang, Yunlong Zhao, Songbai Gui and Xiu-An Yang
    Citation: Journal of Translational Medicine 2025 23:124
    Content type: Research Published on:

  22. Colorectal cancer (CRC) remains a major global health challenge, with high rates of incidence and mortality. This study investigates the role of protein arginine methyltransferase 6 (PRMT6) as an oncogene in C...

    Authors: Xin Zhang, Mingxin Jin, Yali Chu, Fengjun Liu, Hui Qu and Cheng Chen
    Citation: Journal of Translational Medicine 2025 23:74
    Content type: Research Published on:

  23. Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20–30% of CRC patients already present with liver metastas...

    Authors: Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han and Liyong Pu
    Citation: Journal of Translational Medicine 2025 23:59
    Content type: Research Published on:

  24. Small cell neuroendocrine cervical carcinoma is a highly aggressive tumor characterized by early metastasis, a high recurrence rate, and poor prognosis. This study represents the first instance of single-cell ...

    Authors: Tianyou Wang, Li Zhang, Song Mei, Bo Wang, Jiaqi Liu, Weiping Yang, Jiongbo Liao and Chao Wang
    Citation: Journal of Translational Medicine 2025 23:19
    Content type: Research Published on:

  25. Non-Small Cell Lung Cancer (NSCLC) is the leading cause of cancer death worldwide. Although immune checkpoint inhibitors (ICIs) have shown remarkable clinical efficacy, they can also induce a paradoxical cance...

    Authors: Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Laura Scalambra, Maria Sofia Semprini, Olga Maria Pittino, Chiara Cappello, Irene Siracusa, Ilaria Candida Chillico, Martina Di Noia, Cristian Turato, Silvia De Siervi, Francesco Lescai, Teresa Ciavattini…
    Citation: Journal of Translational Medicine 2025 23:2
    Content type: Research Published on:

  26. MicroRNAs (miRNAs) emerge as critical regulators of CD8 + T cell function within the complex tumor microenvironment (TME). This review explores the multifaceted interplay between miRNAs and CD8 + T cells acros...

    Authors: Arefeh Zabeti Touchaei and Sogand Vahidi
    Citation: Journal of Translational Medicine 2024 22:1131
    Content type: Review Published on:

  27. The bone marrow niche is a special microenvironment that comprises elements, including hematopoietic stem cells, osteoblasts, and endothelial cells, and helps maintain their characteristic functions. Here, we ...

    Authors: Zeqi Huang, Zoya Iqbal, Zhe Zhao, Jianquan Liu, A. M. Alabsi, Maryam Shabbir, Ayesha Mahmood, Yujie Liang, Wencui Li and Zhiqin Deng
    Citation: Journal of Translational Medicine 2024 22:1096
    Content type: Review Published on:

  28. Diagnosing infected joint replacements relies heavily on assessing the neutrophil response to bacteria. Bacteria form biofilms on joint replacements. Biofilms are sessile bacterial communities encased in a pro...

    Authors: Robert Manasherob, Shay I. Warren, Prerna Arora, Lyong Heo, Naomi L. Haddock, Ievgen Koliesnik, Diasuke Furukawa, Z. Ngalo Otieno-Ayayo, William J. Maloney, David W. Lowenberg, Stuart B. Goodman and Derek F. Amanatullah
    Citation: Journal of Translational Medicine 2024 22:1041
    Content type: Research Published on:

  29. The use of neoadjuvant chemoradiotherapy (neoCRT) followed by surgery has markedly enhanced the quality of survival in patients suffering from local advanced rectal cancer (LARC). Enhancing this treatment requ...

    Authors: Wenzhao Su, Yuhang Ling, Xiaodong Yang, Yong Wu and Chungen Xing
    Citation: Journal of Translational Medicine 2024 22:1037
    Content type: Research Published on:

  31. Uveal melanoma (UM) is a rare and deadly eye cancer with high metastatic potential. Despite the predominance of malignant cells within the tumor microenvironment, the heterogeneity and underlying molecular fea...

    Authors: Ke Li, Jingzhe Huang, Ying Tan, Jie Sun and Meng Zhou
    Citation: Journal of Translational Medicine 2024 22:1020
    Content type: Research Published on:

  32. Neoadjuvant chemotherapy (NACT) became a standard treatment strategy for patients with inflammatory breast cancer (IBC) because of high disease aggressiveness. However, given the heterogeneity of IBC, no molec...

    Authors: François Bertucci, Arnaud Guille, Florence Lerebours, Michele Ceccarelli, Najeeb Syed, José Adélaïde, Pascal Finetti, Naoto T. Ueno, Steven Van Laere, Patrice Viens, Alexandre De Nonneville, Anthony Goncalves, Daniel Birnbaum, Céline Callens, Davide Bedognetti and Emilie Mamessier
    Citation: Journal of Translational Medicine 2024 22:969
    Content type: Research Published on:

  33. Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors that lacks effective treatment options. Cancer-associated fibroblasts (CAFs), an important component of the tumor microenvironment, a...

    Authors: Bo Gao, Guohua Hu, Boshi Sun, Wenqiang Li and Hao Yang
    Citation: Journal of Translational Medicine 2024 22:937
    Content type: Research Published on:

  34. Cirrhosis represents a significant global health challenge, characterized by high morbidity and mortality rates that severely impact human health. Timely and precise prognostic assessments of liver cirrhosis a...

    Authors: Yinping Zhai, Darong Hai, Li Zeng, Chenyan Lin, Xinru Tan, Zefei Mo, Qijia Tao, Wenhui Li, Xiaowei Xu, Qi Zhao, Jianwei Shuai and Jingye Pan
    Citation: Journal of Translational Medicine 2024 22:933
    Content type: Review Published on:

  35. Research has elucidated that homeobox B9 (HOXB9), an important transcriptional activator, plays a pivotal role in promoting the invasion and metastasis of hepatocellular carcinoma (HCC) cells. However, the mec...

    Authors: Dandan Zhang, Yumin Qiu, Wenming Zhang, Dongnian Du, Yang Liu, Lingpeng Liu, Jiajuan Li, Zehao Chen, Xuzhe Yu, Miao Ye, Wei Wang, Zijing Li and Jianghua Shao
    Citation: Journal of Translational Medicine 2024 22:918
    Content type: Research Published on:

  36. Sarcomas, malignant tumors from mesenchymal tissues, exhibit poor prognosis despite advancements in treatment modalities such as surgery, radiotherapy, and chemotherapy, with doxorubicin being a cornerstone tr...

    Authors: Young-Eun Cho, Soon-Chan Kim, Ha Jeong Kim, Ilkyu Han and Ja-Lok Ku
    Citation: Journal of Translational Medicine 2024 22:889
    Content type: Research Published on:

  37. Traditional genomic profiling and mutation analysis of single cells like Circulating Tumor Cells (CTCs) fails to capture post-translational and functional alterations of proteins, often leading to limited trea...

    Authors: Mahdi Rivandi, André Franken, Liwen Yang, Anna Abramova, Nadia Stamm, Jens Eberhardt, Berthold Gierke, Meike Beer, Tanja Fehm, Dieter Niederacher, Michael Pawlak and Hans Neubauer
    Citation: Journal of Translational Medicine 2024 22:848
    Content type: Research Published on:

  38. Artificial intelligence (AI) can acquire characteristics that are not yet known to humans through extensive learning, enabling to handle large amounts of pathology image data. Divided into machine learning and...

    Authors: Ting Xie, Aoling Huang, Honglin Yan, Xianli Ju, Lingyan Xiang and Jingping Yuan
    Citation: Journal of Translational Medicine 2024 22:799
    Content type: Review Published on:

  39. Pancreatic adenocarcinomas (PAADs) often exhibit a “cold” or immunosuppressive tumor milieu, which is associated with resistance to immune checkpoint blockade therapy; however, the underlying mechanisms are in...

    Authors: Jia Ge, Juan Ge, Gu Tang, Dejun Xiong, Dongyan Zhu, Xiaoling Ding, Xiaorong Zhou and Mengmeng Sang
    Citation: Journal of Translational Medicine 2024 22:775
    Content type: Research Published on:

  40. Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression mediated by CCR8+ Tregs observed in breast and lung...

    Authors: Qian Chen, Meiying Shen, Min Yan, Xiaojian Han, Song Mu, Ya Li, Luo Li, Yingming Wang, Shenglong Li, Tingting Li, Yingying Wang, Wang Wang, Zhengqiang Wei, Chao Hu and Aishun Jin
    Citation: Journal of Translational Medicine 2024 22:709
    Content type: Research Published on:

  41. T cells play a pivotal role in chemotherapy-triggered anti-tumor effects. Emerging evidence underscores the link between impaired anti-tumor immune responses and resistance to paclitaxel therapy in triple-nega...

    Authors: Yu Hu, Xiaohan Lou, Kaili Zhang, Longze Pan, Yueyue Bai, Linlin Wang, Ming Wang, Yan Yan, Jiajia Wan, Xiaohan Yao, Xixi Duan, Chen Ni and Zhihai Qin
    Citation: Journal of Translational Medicine 2024 22:672
    Content type: Research Published on:

  42. Liver cancer is a significant global health challenge, with hepatocellular carcinoma (HCC) being the most prevalent form, characterized by high incidence and mortality rates. Despite advances in targeted thera...

    Authors: Yu Zhang, Weihao Xu, Chuanhui Peng, Shenli Ren and Cheng Zhang
    Citation: Journal of Translational Medicine 2024 22:651
    Content type: Review Published on:

  43. The growing understanding of cancer biology and the establishment of new treatment modalities has not yielded the expected results in terms of survival for Laryngeal Squamous Cell Cancer (LSCC). Early diagnosi...

    Authors: Michela Falco, Chiara Tammaro, Alessia Maria Cossu, Takashi Takeuchi, Rossella Tufano, Michele Ceccarelli, Giuseppe Scafuro, Silvia Zappavigna, Anna Grimaldi, Marianna Scrima, Alessandro Ottaiano, Giovanni Savarese, Antonio Fico, Massimo Mesolella, Morena Fasano, Giovanni Motta…
    Citation: Journal of Translational Medicine 2024 22:647
    Content type: Research Published on:

  44. Cancer-associated fibroblast (CAF)-cancer cell crosstalk (CCCT) plays an important role in tumor microenvironment shaping and immunotherapy response. Current prognostic indexes are insufficient to accurately a...

    Authors: Yuming Xu, Junda Li, Jinming Wang and Feilong Deng
    Citation: Journal of Translational Medicine 2024 22:645
    Content type: Research Published on:

  45. Over the last two decades, tumor-derived RNA expression signatures have been developed for the two most commonly diagnosed tumors worldwide, namely prostate and breast tumors, in order to improve both outcome ...

    Authors: Marianna Talia, Eugenio Cesario, Francesca Cirillo, Domenica Scordamaglia, Marika Di Dio, Azzurra Zicarelli, Adelina Assunta Mondino, Maria Antonietta Occhiuzzi, Ernestina Marianna De Francesco, Antonino Belfiore, Anna Maria Miglietta, Michele Di Dio, Carlo Capalbo, Marcello Maggiolini and Rosamaria Lappano
    Citation: Journal of Translational Medicine 2024 22:597
    Content type: Research Published on:

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2024 22:699

  46. Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment.

    Authors: Siyu Zhou, Baian Tao, Yujie Guo, Jichun Gu, Hengchao Li, Caifeng Zou, Sichong Tang, Shuheng Jiang, Deliang Fu and Ji Li
    Citation: Journal of Translational Medicine 2024 22:557
    Content type: Research Published on:

  47. Hepatocellular carcinoma (HCC) causes significant cancer mortality worldwide. Cancer organoids can serve as useful disease models by high costs, complexity, and contamination risks from animal-derived products...

    Authors: Azza M. El-Derby, Mennatallah A. Khedr, Nehal I. Ghoneim, Mahmoud M. Gabr, Sherry M. Khater and Nagwa El-Badri
    Citation: Journal of Translational Medicine 2024 22:487
    Content type: Research Published on:

  48. Extracellular vesicles (EVs) are lipid bilayer structures released by all cells and widely distributed in all biological fluids. EVs are implicated in diverse physiopathological processes by orchestrating cell...

    Authors: Soheil Rahmati, Aysan Moeinafshar and Nima Rezaei
    Citation: Journal of Translational Medicine 2024 22:452
    Content type: Review Published on:

  49. Current cancer therapies often fall short in addressing the complexities of malignancies, underscoring the urgent need for innovative treatment strategies. RNA interference technology, which specifically suppr...

    Authors: Junxiao Chen, Ziyuan Liu, Haiting Fang, Qing Su, Yiqi Fan, Luyao Song and Shuai He
    Citation: Journal of Translational Medicine 2024 22:395
    Content type: Research Published on:

  50. Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with high probability of recurrence and distant metastasis. Liver metastasis is the predominant metastatic mode developed in most pancreatic cance...

    Authors: Xiaohong Liu, Bo Ren, Yuan Fang, Jie Ren, Xing Wang, Minzhi Gu, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Lei You and Yupei Zhao
    Citation: Journal of Translational Medicine 2024 22:393
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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