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Fibrosis

Section edited by Mary Salvatore

The Fibrosis section aims to gather current high-quality research to better understand the process of normal tissue repair as well as the pathogenetic mechanisms responsible for the onset and progression of tissue fibrosis that leads to organ dysfunction and failure. Fibrosis is the common denominator in a variety of chronic diseases including idiopathic pulmonary fibrosis, liver cirrhosis, and ulcerative colitis, among others. These fibrotic diseases affect a vast number of people across the world significantly impacting the quality of their life and increasing health care costs. Prolonged fibrosis is related to increased cancer risk. 

The section will focus on high-quality research from basic science to clinical trials. The expert members of our Editorial Board are committed to ensuring a productive scientific discussion and welcome your thought-provoking contributions to Fibrosis.
 

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  1. Breast cancer incidence rates have been increasing globally. Cancer-associated fibroblasts (CAFs), key stromal components of the tumor microenvironment (TME), play crucial roles in tumor growth by dynamically ...

    Authors: Lifang Zhang, Keqin Wang, Jianbo Zhang, Xianzhe Qian, Xiaoan Zhang, Yi Wang, Quan Hu, Ziyi Zhan, Wending Hu, Hui Lin, Xiaoming Liu and Lixia Xiong
    Citation: Journal of Translational Medicine 2025 23:784
    Content type: Research Published on:

  2. Accurate prediction of pathological complete response (pCR) to neoadjuvant chemotherapy has significant clinical utility in the management of breast cancer treatment. Although multimodal deep learning models h...

    Authors: Taishi Nishizawa, Takouhie Maldjian, Zhicheng Jiao and Tim Q. Duong
    Citation: Journal of Translational Medicine 2025 23:774
    Content type: Research Published on:

  3. Interstitial lung disease (ILD) is a common and severe comorbidity of rheumatoid arthritis (RA), yet reliable diagnostic biomarkers remain lacking. Alveolar type II (ATII) cells are widely recognized to play a...

    Authors: Chuanhui Yao, Xun Gong, Biyue Shang, Dan Dou, Weixiang Liu, Hui Xu, Yuchen Yang, Xieli Ma, Qiuwei Peng, Juan Jiao, Xiaopo Tang, Congmin Xia, Peng Chen and Quan Jiang
    Citation: Journal of Translational Medicine 2025 23:765
    Content type: Research Published on:

  4. Fibrogenesis is a common pathological feature of endometriotic lesions and contributes to the development of endometriosis-associated chronic pelvic pain and infertility. TGF-β is a critical factor in the indu...

    Authors: Mian Liu, Yi Gong, Hong Cai, Rui Hua, Hong Li, Zhe Wang, Yao Zhou, Yanlin Ma and Song Quan
    Citation: Journal of Translational Medicine 2025 23:763
    Content type: Research Published on:

  5. Diabetic kidney disease (DKD) is the major cause of chronic kidney failure, with tubulointerstitial fibrosis playing a crucial role in disease development. Identifying fibrosis-related genes is crucial for imp...

    Authors: Lijuan Li, Mi Tao, Xueyun Gao, Quan Cao, Zejing Liao, Feng Chen, Ayinigaer Yusufu, Haihang Nie, Ziyue Zeng, Kai Huang, Xuan Deng, Ping Gao and Xiaoyan Wu
    Citation: Journal of Translational Medicine 2025 23:742
    Content type: Research Published on:

  7. Chronic pancreatitis (CP) is characterized by progressive fibrosis and the activation of pancreatic stellate cells (PSCs). As major producers of collagen-I and fibronectin, PSCs play important roles in pancrea...

    Authors: Zheng Lian, Wei-hong Du, Paizi-guli Tusup-han and Yu-xiang Zhang
    Citation: Journal of Translational Medicine 2025 23:694
    Content type: Research Published on:

  8. Given the rising prevalence of liver fibrosis, there is an urgent need to improve the effective diagnostic methods and treatment of liver fibrosis. Although GPCRs are involved in various physiological and path...

    Authors: Zhemin Shi, Qi Liu, Mengxia Zhang, Xiaoxiao Du, Yifan He, Lina Zheng, Wei Hong, Tao Han and Kun Zhang
    Citation: Journal of Translational Medicine 2025 23:632
    Content type: Research Published on:

  9. Renal fibrosis is characterized by the formation of scar tissue in the kidney parenchyma. Obesity, with its rising global incidence, has become a significant cause of renal fibrosis. This study investigates th...

    Authors: Haoan Yi, Yibing Jiang, Wei Li, Ling Shen, Wei Zhang, Shude Li, Yushan Xu and Fei Li
    Citation: Journal of Translational Medicine 2025 23:611
    Content type: Research Published on:

  10. Breast cancer progression and metastasis involve the action of multiple transcription factors in tumors and in the cells of the tumor microenvironment (TME) and understanding how these transcription factors ar...

    Authors: Stephanie M. Wilk, Kihak Lee, Caitlyn C. Castillo, Mohamed Haloul, Alexa M. Gajda, Virgilia Macias, Elizabeth L. Wiley, Zhengjia Chen, Xinyi Liu, Xiaowei Wang, Maria Sverdlov, Kent F. Hoskins and Ekrem Emrah Er
    Citation: Journal of Translational Medicine 2025 23:599
    Content type: Research Published on:

  11. Salivary gland (SG) fibrosis is characterized by aberrant extracellular matrix deposition and myofibroblast activation, leading to irreversible glandular dysfunction. Current treatments remain ineffective in r...

    Authors: Boyuan Peng, Xufei Guo, Jialing Kang, Shijiao Pan, Lili Wei, Lianhao Wang, Bo Li, Guangli Han and Yong Cheng
    Citation: Journal of Translational Medicine 2025 23:593
    Content type: Research Published on:

  12. It has been established that inflammatory factors are involved in the formation of pathological scars. Therefore, pathological scars are regarded to be highly associated with chronic inflammation, whereas what...

    Authors: Ning Yang, Hao Zhang, Yuheng Zhang, Bin Lin, Rong Huang, Tingting Cui and Xueyong Li
    Citation: Journal of Translational Medicine 2025 23:569
    Content type: Research Published on:

  13. Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by vascular remodeling and involves Endothelial-to-Mesenchymal transition (EndMT) in pulmonary artery endothelial cells (PAECs)...

    Authors: Qiuhong Jiao, Xiufeng Xu, Longwu Xu, Yuying Wang, Shulan Pang, Jie Hao, Xiaohong Liu, Yudan Zhao, Wanpeng Qi, Limin Qin, Tao Huang, Jingtian Li and Tao Wang
    Citation: Journal of Translational Medicine 2025 23:524
    Content type: Research Published on:

  14. Pulmonary fibrosis (PF) is a chronic, progressive interstitial lung disease characterized by excessive deposition of extracellular matrix (ECM) and abnormal fibroblast proliferation, which is mainly caused by ...

    Authors: Mengna Jiang, Wenxia Bu, Xuehai Wang, Jialing Ruan, Weijian Shi, Siqi Yu, Lizhen Huang, Peng Xue, Juan Tang, Xinyuan Zhao, Liling Su and Demin Cheng
    Citation: Journal of Translational Medicine 2025 23:515
    Content type: Review Published on:

  16. Intestinal fibrosis is a serious complication of Crohn’s disease (CD), often resulting from chronic inflammation. However, the precise mechanisms through which inflammation induces intestinal fibrosis remain i...

    Authors: Lu Wang, Shu Wang, Junjie Lin, Jiajia Li, Mingyuan Wang, Jiang Yu, Junjian Sun, Nana Tang, Chunhua Jiao, Jingjing Ma, Xiaojing Zhao and Hongjie Zhang
    Citation: Journal of Translational Medicine 2025 23:452
    Content type: Research Published on:

  17. High fibrosis of the tumor microenvironment (TME) not only impedes the effective infiltration of T cells but also serves as a physical barrier to inhibit the penetration of chemotherapy drugs. Triple-negative ...

    Authors: Yuying Tan, Yong-Guang Yang, Xiaoying Zhang, Lei Zhao, Xiaocong Wang and Wentao Liu
    Citation: Journal of Translational Medicine 2025 23:432
    Content type: Research Published on:

  18. Obesity has been associated with several pancreatic disorders and is an important risk factor for pancreatic cancer. Nevertheless, the role of lipids in the early steps of carcinogenesis is unknown. Although w...

    Authors: Sonia Frendi, Anaïs Chassac, Killian Veron, Jérôme Raffenne, Rémy Nicolle, Miguel Albuquerque, Valérie Paradis, Anne Couvelard, Jérôme Cros and Vinciane Rebours
    Citation: Journal of Translational Medicine 2025 23:416
    Content type: Research Published on:

  19. Chronic kidney disease (CKD) has emerged as a major health problem worldwide. Previous studies have shown that specific miRNA expression profiles of patients with CKD are significantly changed. In this study, ...

    Authors: Cui Huimin, Zhao Yuxin, Wang Peng, Gong Wei, Lin Hong, Li Na and Yang Jianjun
    Citation: Journal of Translational Medicine 2025 23:387
    Content type: Research Published on:

  20. Abnormal glycolytic metabolism plays a significant role in pulmonary vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH), yet the specific mechanisms remain unclear. The primary objective ...

    Authors: Xuan Gao, Youli Fan, Guijia Wang, Jiangjiang Xu, Runwei Deng, Jiangwei Song, Binfeng Sun, Yongbing Wang, Zixuan Wu, Ruyi Jia, Jing Huang, Huiyu He, Lei Gao, Yihao Zhang, Na Sun and Bingxiang Wu
    Citation: Journal of Translational Medicine 2025 23:373
    Content type: Research Published on:

  21. Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by the excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs). Recent studies indicate that Mitochondrial fusion pr...

    Authors: Rui Wang, Jie Wang, Jing Yu, Zhiqiang Li, Minfang Zhang, Yuhu Chen, Fen Liu, Dongmei Jiang, Jingfei Guo, Xiaomei Li and Yun Wu
    Citation: Journal of Translational Medicine 2025 23:366
    Content type: Research Published on:

  22. To identify potential therapeutic targets and evaluate the safety profiles for Idiopathic Pulmonary Fibrosis (IPF) using a comprehensive multi-omics approach.

    Authors: Zhuofeng Wen, Weixuan Liang, Ziyang Yang, Junjie Liu, Jing Yang, Runge Xu, Keye Lin, Jia Pan and Zisheng Chen
    Citation: Journal of Translational Medicine 2025 23:337
    Content type: Research Published on:

  23. We have previously reported that the serum levels of gut-derived tryptophan metabolite indole-3-propionic acid (IPA) are lower in individuals with liver fibrosis. Now, we explored the transcriptome and DNA met...

    Authors: Mariana Ilha, Ratika Sehgal, Johanna Matilainen, Kirsi Rilla, Dorota Kaminska, Shrey Gandhi, Ville Männistö, Charlotte Ling, Stefano Romeo, Päivi Pajukanta, Eija Pirinen, Kirsi A. Virtanen, Kirsi H. Pietiläinen, Maija Vaittinen and Jussi Pihlajamäki
    Citation: Journal of Translational Medicine 2025 23:253
    Content type: Research Published on:

  24. Subretinal fibrosis is an important cause of visual loss in age-related macular degeneration, but its mechanism remains unclear. This study aims to investigate the role of macrophage-to-myofibroblast transitio...

    Authors: Qi Zhang, Bing Lu, Lei He, Kai Fang, Xiaolong Zhu, Tianbing Chen, Yingying Zhu, Yinping Liu and Pengfei Zhang
    Citation: Journal of Translational Medicine 2025 23:251
    Content type: Research Published on:

  25. Cardiac fibrosis is a physiological process that involves the formation of scar tissue in the heart in response to injury or damage. This process is initially a protective measure characterized by enhanced fib...

    Authors: Wutian Rao, Dan Li, Qinghang Zhang, Tianbao Liu, Zhengying Gu, Lin Huang, Jinjie Dai, Jiayi Wang and Xumin Hou
    Citation: Journal of Translational Medicine 2025 23:242
    Content type: Review Published on:

  27. Metabolic dysfunction-associated steatohepatitis (MASH) is a large group of metabolic diseases that are hazardous to human health. Endothelial-to-mesenchymal transition (EndMT) mediated myofibroblast activatio...

    Authors: Ting Wang, Bangguo Liu, Juan Huang, Qixin Zhao, Hongping Shen, Tao Bi, Zengjin Liu, Yong Dai and Qin Sun
    Citation: Journal of Translational Medicine 2025 23:195
    Content type: Research Published on:

  28. Fibrosis is a common and integral pathological feature in various chronic diseases, capable of affecting any tissue or organ. Fibrosis within deep fascia is implicated in many myofascial disorders, including g...

    Authors: Weizhi Zhao, Zongchao Li, Suzhen Ma, Wen Chen, Zhengqing Wan, Lin Zhu, Liangjun Li and Danling Wang
    Citation: Journal of Translational Medicine 2025 23:192
    Content type: Research Published on:

  29. Scar formation is a common end-point of the wound healing process, but its mechanisms, particularly in relation to abnormal scars such as hypertrophic scars and keloids, remain not fully understood. This study...

    Authors: Minwoo Kang, Ung Hyun Ko, Eun Jung Oh, Hyun Mi Kim, Ho Yun Chung and Jennifer H. Shin
    Citation: Journal of Translational Medicine 2025 23:168
    Content type: Research Published on:

  30. Chronic cerebral hypoperfusion (CCH) is a critical pathophysiological mechanism underlying cerebral small vessel disease (CSVD). Accumulating evidence have demonstrated that resident pericytes and deposit extr...

    Authors: Qingrui Duan, Zhiyang Liu, Yuxuan Xing, Haifeng Huang, Lin Zhu, Jiaxuan Liu, Peikun He, Guixian Ma, Yuhu Zhang, Kun Nie, Yuyuan Gao and Lijuan Wang
    Citation: Journal of Translational Medicine 2025 23:161
    Content type: Research Published on:

  32. Tumor-associated fibrosis modifies the tumor microenvironment (TME), hinders the infiltration and activity of cytotoxic immune cells, and is a critical pathological process leading to the ineffectiveness of tu...

    Authors: Yingqi Yang, Haohan Sun, Hongkai Yu, Luyao Wang, Chang Gao, Haokun Mei, Xiaomeng Jiang and Minghui Ji
    Citation: Journal of Translational Medicine 2025 23:123
    Content type: Research Published on:

  33. The partial epithelial-mesenchymal transition (EMT) is emerging as a significant mechanism in diabetic nephropathy (DN). LOX is a copper amine oxidase conventionally thought to act by crosslinking collagen. Ho...

    Authors: Yicheng Lu, Heyangzi Li, Mohan Chen, Yicheng Lin and Xiaoming Zhang
    Citation: Journal of Translational Medicine 2025 23:35
    Content type: Research Published on:

  34. Pulmonary fibrosis is characterized by progressive lung scarring, leading to a decline in lung function and an increase in morbidity and mortality. This study leverages single-cell sequencing and machine learn...

    Authors: Yong Zhou, Zhongkai Tong, Xiaoxiao Zhu, Chunli Wu, Ying Zhou and Zhaoxing Dong
    Citation: Journal of Translational Medicine 2025 23:3
    Content type: Research Published on:

  35. Scutellaria baicalensis Georgi, a traditional Chinese herb, is known for its various biological effects, including antibacterial, anti-inflammatory, antioxidative, and antitumor properties. However, the function ...

    Authors: Yunheng Yang, Yi Liu, Yujie Cheng, Honglin He, Ailing Liang, Zheng Pan, Yuanyuan Liu and Zhiwei Chen
    Citation: Journal of Translational Medicine 2024 22:1138
    Content type: Research Published on:

  36. Glycolysis plays a major role in progression of idiopathic pulmonary fibrosis (IPF). Here, we aim to explore the predictive signature based on glycolysis-related genes for predicting the prognosis and identifi...

    Authors: Yuechong Xia, Fang Zhou, Hongyan Hui, Liping Dai and Songyun Ouyang
    Citation: Journal of Translational Medicine 2024 22:1114
    Content type: Research Published on:

  37. Idiopathic pulmonary fibrosis (IPF) stands as a significant contributor to global mortality rates. Presently, there exists a dearth of effective anti-fibrotic treatments for this condition. While itraconazole ...

    Authors: Caizhe Pan, Hao Wei, Bi Chen, Lei Wu, Jiayao Song, Qing Zhang, Xinglong Wu, Guibai Liang, Wenhao Chen, Yingshuo Wang and Yicheng Xie
    Citation: Journal of Translational Medicine 2024 22:1058
    Content type: Research Published on:

  38. Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Fi...

    Authors: Pengfei Gao, Yanjiao Lu, Kun Tang, Wei Wang, Tongsheng Wang, Yingwei Zhu, Jianping Zhao and Yimin Mao
    Citation: Journal of Translational Medicine 2024 22:1051
    Content type: Research Published on:

  39. A significant research gap exists regarding the role of tissue exosomes in intrauterine adhesions (IUAs). This study aims to investigate the involvement of miR-195-5p and its regulatory network in IUAs through...

    Authors: Jia-ming Chen, Qiao-yi Huang, Wei-hong Chen, Jin-xiang Wu, Ling-tao Zheng, Hui-jie You, Yan-chuan Shi, Shu Lin and Qi-rong Shi
    Citation: Journal of Translational Medicine 2024 22:1050
    Content type: Research Published on:

  41. Drug discovery strongly relies on the thorough evaluation of preclinical experimental studies. In the context of pulmonary fibrosis, micro-computed tomography (µCT) and histology are well-established and compl...

    Authors: Elena Vincenzi, Martina Buccardi, Erica Ferrini, Alice Fantazzini, Eugenia Polverini, Gino Villetti, Nicola Sverzellati, Andrea Aliverti, Curzio Basso, Francesca Pennati and Franco Fabio Stellari
    Citation: Journal of Translational Medicine 2024 22:1040
    Content type: Research Published on:

  42. Interstitial fibrosis and tubular atrophy (IFTA) is a critical factor in the prognosis of kidney health. Currently, IFTA quantitation in kidney biopsy samples is crucial for diagnosis and assessing disease sev...

    Authors: Marta Clos-Sansalvador, Omar Taco, Paula Rodríguez-Martínez, Sergio G. Garcia, Miriam Font-Morón, Jordi Bover, Anna Vila-Santandreu, Marcella Franquesa, Javier Juega and Francesc E. Borràs
    Citation: Journal of Translational Medicine 2024 22:1030
    Content type: Research Published on:

  43. Renal fibrosis is a key process in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD), while the intricate mechanisms of renal fibrosis remain obscure. While the signal-transducing ...

    Authors: Yuan Yuan, Xiao Wei, Xi Xiong, Xiong Wang, Wei Jiang, Qihui Kuang, Kai Zhu, Chen Chen, Jingzheng Gan, Junjie Li, Jun Yang, Lili Li and Pengcheng Luo
    Citation: Journal of Translational Medicine 2024 22:1018
    Content type: Research Published on:

  44. Pulmonary fibrosis is a serious interstitial lung disease with no viable treatment except for lung transplantation. Glucagon-like peptide-1 receptor (GLP-1R), commonly regarded as an antidiabetic target, exert...

    Authors: Chenyang Liu, Qun Zhang, Hong Zhou, Linling Jin, Chang Liu, Mingxia Yang, Xinyun Zhao, Wenqiu Ding, Weiping Xie and Hui Kong
    Citation: Journal of Translational Medicine 2024 22:954
    Content type: Research Published on:

  45. Metabolic dysfunction-associated steatohepatitis (MASH) is a growing global health concern with no effective pharmacological treatments. SNP-630, a newly developed synthetic molecule with multiple mechanisms o...

    Authors: Hsin-Tien Ho, Yu-Lueng Shih, Tien-Yu Huang, Wen-Hui Fang, Chang-Hsien Liu, Jung-Chun Lin, Chih-Weim Hsiang, Kai-Min Chu, Cheng-Huei Hsiong, Guan-Ju Chen, Yung-En Wu, Jia-Yu Hao, Chih-Wen Liang and Oliver Yoa-Pu Hu
    Citation: Journal of Translational Medicine 2024 22:936
    Content type: Research Published on:

  46. Idiopathic pulmonary fibrosis (IPF) is a chronic and lethal lung disorder for which effective treatments remain limited. Recent investigations revealed a potential link between altered glucose metabolism and t...

    Authors: Chenxi Zeng, Huihui Yue, Congjian Wang, Xuetao Ju, Tianlai Wang, Xiangning Fu, Qing Zhou, Huilan Zhang, Long He, Jun Yu and Yi Wang
    Citation: Journal of Translational Medicine 2024 22:910
    Content type: Research Published on:

  47. Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease of unknown etiology. Despite the increasing global incidence and poor prognosis, the exact pathogenic mechanisms remai...

    Authors: Meng Tu, Chunya Lu, Hongxia Jia, Shanshan Chen, Yan Wang, Jing Li, Jiuling Cheng, Ming Yang and Guojun Zhang
    Citation: Journal of Translational Medicine 2024 22:885
    Content type: Research Published on:

  48. Myocardial fibrosis, a hallmark of heart disease, is closely associated with macrophages, yet the genetic pathophysiology remains incompletely understood. In this study, we utilized integrated single-cell tran...

    Authors: Yong-Zheng Zhang, Yang Wu, Meng-jia Li, Aerzu Mijiti and Lu-Feng Cheng
    Citation: Journal of Translational Medicine 2024 22:839
    Content type: Research Published on:

  50. High levels of lactate are positively associated with prognosis and mortality in pulmonary hypertension (PH). Lactate dehydrogenase A (LDHA) is a key enzyme for the production of lactate. This study is underta...

    Authors: Daiqian Wu, Shuo Wang, Fengxian Wang, Qing Zhang, Zhen Zhang and Xingbing Li
    Citation: Journal of Translational Medicine 2024 22:738
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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