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Immune RadioBiology

Section edited by Claire Vanpouille-Box

The Immune RadioBiology section is interested in innovative research that investigate the crosstalk between ionizing radiations (IR), the tumor microenvironment (TME) and host immunity. 

Studies considered for publication include (but not limited to) those investigating the mechanisms of radiation-induced anti-tumor immune responses, the immune-stimulatory and immuno-suppressive properties of ionizing radiation from all sources (X-rays, FLASH-RT, protons, carbon ion and radionuclides), biomarkers predictive of immune response, immune escape mechanisms elicited by IR and radioresistance. Importantly, the section welcomes translational and clinical studies assessing the combination of IR with immunotherapies (IT) with an emphasis on clinical response and outcome.

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  1. Ionizing radiation can influence the antitumor immune response, either activating or suppressing the immune system depending on the tumor type and radiotherapy modality. While photon radiation (RT) combined wi...

    Authors: Hélène Burckel, Anaïs Nicol, Carole Mura, Marc Rousseau, Jolie Bou-Gharios, Lisa Froidurot, Corentin Richard, Véronique Morgand, Pierre-Antoine Laurent, Emeric Limagne, Romain Boidot, Georges Noël and Céline Mirjolet
    Citation: Journal of Translational Medicine 2025 23:360
    Content type: Research Published on:

  2. Radiotherapy is a key treatment for colorectal cancer (CRC), particularly rectal cancer; however, many patients are resistant to radiation. While it has been shown that CHI3L1 is associated with CRC progressio...

    Authors: Ming Jin, Hui Liu, Zhen Zheng, Shuai Fang, Yang Xi and Kaitai Liu
    Citation: Journal of Translational Medicine 2025 23:357
    Content type: Research Published on:

  3. Radioresistance presents a major challenge in the treatment of cervical cancer (CC). Apoptotic tumor cells can create an “onco-regenerative niche,” contributing to radioresistance. However, the intercellular s...

    Authors: Yuan-Run Deng, Qiao-Zhi Wu, Wan Zhang, Hui-Ping Jiang, Cai-Qiu Xu, Shao-Cheng Chen, Jing Fan, Sui-Qun Guo and Xiao-Jing Chen
    Citation: Journal of Translational Medicine 2025 23:328
    Content type: Research Published on:

  4. Monitoring individual therapy responses of patients with cancer represents a major clinical challenge providing the basis to early identify metastases and cancer relapse. We previously demonstrated that radio-...

    Authors: Selina Gies, Patrick Melchior, Istvan Molnar, Gregor Olmes, Russalina Stroeder, Tanja Tänzer, Maike Pohlers, Moritz Schäfer, Laura Theobald, Martina Sester, Erich Franz Solomayer and Barbara Walch-Rückheim
    Citation: Journal of Translational Medicine 2025 23:321
    Content type: Research Published on:

  5. Radiation-induced lung injury (RILI) is the most common complication experienced by patients with thoracic tumors after radiotherapy. Among patients receiving thoracic tumor radiotherapy, 14.6–37.2% develop RI...

    Authors: Shihua Deng, Yueyan Yang, Shuang He, Zixin Chen, Xun Xia, Ting Zhang, Qing Yin, Teng Liu, Dongming Wu, Kejian Pan and Ying Xu
    Citation: Journal of Translational Medicine 2025 23:237
    Content type: Research Published on:

  6. Photon radiation has been shown to stimulate the secretion of radioresistant factors from tumor cells, ultimately promoting tumor angiogenesis and metastasis. On the other hand, heavy-ion radiotherapy has been...

    Authors: Hao Huang, Ying Xu, Zi Guo, Miaomiao Zhang, Wanshi Li, Yidan Song, Jing Nie, Wentao Hu, Tom K. Hei and Guangming Zhou
    Citation: Journal of Translational Medicine 2025 23:235
    Content type: Research Published on:

  7. The persistent accumulation of senescence cells is one of the characteristics of radiation-induced skin injury (RISI), leading to fibrosis and impaired healing. However, the reasons why these senescence cells ...

    Authors: Gaoyu Liu, Yan Chen, Shijie Dai, Gang Wu, Fulong Wang, Wanchao Chen, Lingling Wu, Peng Luo and Chunmeng Shi
    Citation: Journal of Translational Medicine 2025 23:196
    Content type: Research Published on:

  8. Radiotherapy is commonly used for locoregionally advanced NSCLC, but radioresistance is a clinical challenge. The long non-coding RNA CBR3-AS1 mediates radioresistance in NSCLC, yet the underlying molecular me...

    Authors: Songliu Hu, Ning Zhan, Jian Li, Liqun Wang, Yiyan Liu, Ke Jin, Yixuan Wang, Juxuan Zhang, Yiyang Chen, Yang Bai, Yichong Wang, Lishuang Qi and Shilong Liu
    Citation: Journal of Translational Medicine 2025 23:191
    Content type: Research Published on:

  9. The widespread application of nuclear technology has markedly heightened the risk of extensive, uncontrolled exposure to radiation. Nevertheless, in contrast to external irradiation, the biological impacts and...

    Authors: Ping Yang, Hao Bai, Tao Yan, Xiaopeng Xu, Xiaoyou Tang, Bin Song, Yulan Liu, Yunyun Lu, Pengfei Liu, Wenling Tu, Yuhong Shi and Shuyu Zhang
    Citation: Journal of Translational Medicine 2025 23:180
    Content type: Research Published on:

  10. Cervical cancer is a common malignancy among women, and radiotherapy remains a primary treatment modality across all disease stages. However, resistance to radiotherapy frequently results in treatment failure,...

    Authors: Yun Teng, Hongmei Zhao, Guoqing Xue, Guohui Zhang, Yanbin Huang, Wei Guo, Kun Zou and Lijuan Zou
    Citation: Journal of Translational Medicine 2025 23:44
    Content type: Research Published on:

  11. Radiotherapy sensitivity is associated with the prognosis of patients with tongue squamous cell carcinoma (TSCC). In the present study, we proposed to explore the specific mechanism of interventional radiology...

    Authors: Songling Hu, Xiaofei Li, Bin Yang, Tian Yu, Fangyu Yi, Xiurong Qin, Cong Chen, Can Wang, Xin Yu and Jing Zhu
    Citation: Journal of Translational Medicine 2024 22:1082
    Content type: Research Published on:

  12. Histone deacetylase inhibitors (HDACis) have shown a significant antitumor effect in clinical studies, and PXD101 is a novel HDACi which can cross the blood–brain barrier. In this study, we showed that PXD101 ...

    Authors: Xiaohong Hu, Peijun Zhou, Xingzhi Peng, Yiting Ouyang, Dan Li, Xia Wu and Lifang Yang
    Citation: Journal of Translational Medicine 2024 22:1047
    Content type: Research Published on:

  13. Although the representative treatment for colorectal cancer (CRC) is radiotherapy, cancer cells survive due to inherent radioresistance or resistance acquired after radiation treatment, accelerating tumor mali...

    Authors: Jae Yeon Choi, Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, Incheol Shin and In Hwa Bae
    Citation: Journal of Translational Medicine 2024 22:980
    Content type: Research Published on:

  14. We aimed to determine the potential predictive value of the intra-tumoral microbiome as a marker of the response to external beam radiation therapy (EBRT) in cervical cancer (CC).

    Authors: Zhongyan Dou, Conghui Ai, Jinping Zhang, Kangming Li, Meiping Jiang, Xingrao Wu, Chunfang Zhao, Zheng Li and Lan Zhang
    Citation: Journal of Translational Medicine 2024 22:972
    Content type: Research Published on:

  15. Radiation-induced liver fibrosis (RILF) is a common manifestation of radiation-induced liver injury (RILI) and is caused primarily by activated hepatic stellate cells (HSCs). Circular RNAs (circRNAs) play crit...

    Authors: Peitao Zhou, Yixun Deng, Yining Sun, Dehua Wu and Yuhan Chen
    Citation: Journal of Translational Medicine 2024 22:884
    Content type: Research Published on:

  16. Radiation-induced oral mucositis (RIOM) is a prevalent oral complication that occurs in individuals undergoing radiotherapy or radiation treatment for head and neck tumors. The presence of oral mucosal rupture...

    Authors: Leifeng Liang, Mei Gan, Huanshuo Miao, Jinchi Liu, Chunhong Liang, Jinqiu Qin, Kaian Ruan, Haisheng Zhu, Jinghua Zhong and Zhan Lin
    Citation: Journal of Translational Medicine 2024 22:863
    Content type: Research Published on:

  17. Radioresistance and immune escape are crucial reasons for unsatisfactory therapeutic effects of glioblastoma (GBM). Although triggering receptor expressed on myeloid cells-2 (TREM2) involved in forming immunos...

    Authors: Hui Qiu, Zhiying Shao, Xin Wen, Debao Qu, Zhengyang Liu, Ziqin Chen, Xinyan Zhang, Xin Ding and Longzhen Zhang
    Citation: Journal of Translational Medicine 2024 22:688
    Content type: Research Published on:

  18. The combination of immune checkpoint inhibitors with radiotherapy can enhance the immunomodulation by RT and reduce the growth of distant unirradiated tumors (abscopal effect); however, the results are still n...

    Authors: WeiZhou Wang, YunXue Zheng, ZhouXue Wu, Min Wu, Yue Chen, Yan Zhang, ShaoZhi Fu and JingBo Wu
    Citation: Journal of Translational Medicine 2024 22:657
    Content type: Research Published on:

  19. Telomerase, by safeguarding damaged telomeres and bolstering DNA damage repair, has the capacity to heighten the radioresistance of tumour cells. Thus, in turn, can compromise the efficacy of radiotherapy (RT)...

    Authors: Yawei Bao, Zhipeng Pan, Luqi Zhao, Jieping Qiu, Jingjing Cheng, Lei Liu and Dong Qian
    Citation: Journal of Translational Medicine 2024 22:519
    Content type: Research Published on:

  20. Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care. A central impediment to treatment is the ...

    Authors: Masih Tazhibi, Nicholas McQuillan, Hong-Jian Wei, Matthew Gallitto, Ethan Bendau, Andrea Webster Carrion, Xander Berg, Danae Kokossis, Xu Zhang, Zhiguo Zhang, Chia-Ing Jan, Akiva Mintz, Robyn D. Gartrell, Hasan R. Syed, Adriana Fonseca, Jovana Pavisic…
    Citation: Journal of Translational Medicine 2024 22:320
    Content type: Research Published on:

  21. Tumor-associated macrophages (TAMs) play a pivotal role in reshaping the tumor microenvironment following radiotherapy. The mechanisms underlying this reprogramming process remain to be elucidated.

    Authors: Haonan Yang, Zheng Lei, Jiang He, Lu Zhang, Tangmin Lai, Liu Zhou, Nuohan Wang, Zheng Tang, Jiangdong Sui and Yongzhong Wu
    Citation: Journal of Translational Medicine 2024 22:306
    Content type: Research Published on:

  22. Bladder cancer (BC) is the most common urinary tract malignancy. Aurora kinase B (AURKB), a component of the chromosomal passenger protein complex, affects chromosomal segregation during cell division. Mitotic...

    Authors: Linzhi Li, Pengcheng Jiang, Weimin Hu, Fan Zou, Ming Li, Ting Rao, Yuan Ruan, Weimin Yu, Jinzhuo Ning and Fan Cheng
    Citation: Journal of Translational Medicine 2024 22:295
    Content type: Research Published on:

  23. Non-small cell lung cancer (NSCLC) often exhibits resistance to radiotherapy, posing significant treatment challenges. This study investigates the role of SMAD3 in NSCLC, focusing on its potential in influenci...

    Authors: Fushi Han, Shuzhen Chen, Kangwei Zhang, Kunming Zhang, Meng Wang and Peijun Wang
    Citation: Journal of Translational Medicine 2024 22:288
    Content type: Research Published on:

  24. We aimed to investigate the effects of PinX1 on non-small cell lung cancer(NSCLC) radiosensitivity and radiotherapy-associated tumor immune microenvironment and its mechanisms.

    Authors: Jieping Qiu, Ying Xia, Yawei Bao, Jingjing Cheng, Lei Liu and Dong Qian
    Citation: Journal of Translational Medicine 2024 22:228
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:415

  25. Radioresistance is a primary factor contributing to the failure of rectal cancer treatment. Immune suppression plays a significant role in the development of radioresistance. We have investigated the potential...

    Authors: Junxian Liang, Limin Liao, Lang Xie, WenWen Tang, Xiang Yu, Yinghao Lu, Hongzhen Chen, Juanli Xu, Lei Sun, Huanmei Wu, Chunhui Cui and Yujing Tan
    Citation: Journal of Translational Medicine 2024 22:117
    Content type: Research Published on:

  26. Radioresistance and lymph node metastasis are common phenotypes of refractory oral squamous cell carcinoma (OSCC). As a result, understanding the mechanism for radioresistance and metastatic progression is urg...

    Authors: Hui-Wen Chiu, Hsin-Lun Lee, Hsun-Hua Lee, Hsiao-Wei Lu, Kent Yu-Hsien Lin, Yuan-Feng Lin and Che-Hsuan Lin
    Citation: Journal of Translational Medicine 2024 22:13
    Content type: Research Published on:

  27. Radiosensitivity of rectal cancer is related to the radiotherapy efficacy and prognosis of patients with rectal cancer, and the genes and molecular mechanisms related to radiosensitivity of rectal cancer have ...

    Authors: Yi Liu, Yanguang Yang, Feng Ni, Guomei Tai, Cenming Yu, Xiaohui Jiang and Ding Wang
    Citation: Journal of Translational Medicine 2023 21:856
    Content type: Research Published on:

  30. KRAS activating mutations are considered the most frequent oncogenic drivers and are correlated with radio-resistance in multiple cancers including non-small cell lung cancer (NSCLC) and colorectal cancer. Althou...

    Authors: Pierre-Antoine Laurent, Marina Milic, Clément Quevrin, Lydia Meziani, Winchygn Liu, Daphné Morel, Nicolas Signolle, Céline Clémenson, Antonin Levy, Michele Mondini and Eric Deutsch
    Citation: Journal of Translational Medicine 2023 21:773
    Content type: Research Published on:

  31. Long non-coding RNA (lncRNA) HOTAIR acts importantly in liver cancer development, but its effect on radioresistance remains poorly understood. Here, our study probed into the possible impact of HOTAIR in radiores...

    Authors: Ruifeng Pei, Le Zhao, Yiren Ding, Zhan Su, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao and Wuyuan Zhou
    Citation: Journal of Translational Medicine 2023 21:752
    Content type: Research Published on:

  32. Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresista...

    Authors: Yanchun Feng, Yingming Jiang, Jun Liu, Jiaqi Liu, Mengchen Shi, Junxiong Chen, Jingdan Zhang, Yu Tian, Xiangling Yang and Huanliang Liu
    Citation: Journal of Translational Medicine 2023 21:738
    Content type: Research Published on:

  33. Radiotherapy can cause kidney injury in patients with cervical cancer. This study aims to investigate the possible molecular mechanisms by which CpG-ODNs (Cytosine phosphate guanine-oligodeoxynucleotides) regu...

    Authors: Deyu Zhang, Shitai Zhang, Zheng He and Ying Chen
    Citation: Journal of Translational Medicine 2023 21:679
    Content type: Research Published on:

  34. Gene expression signatures can be used as prognostic biomarkers in various types of cancers. We aim to develop a gene signature for predicting the response to radiotherapy in glioma patients.

    Authors: Xiaonan Zhang, Qiannan Ren, Zhiyong Li, Xiaolin Xia, Wan Zhang, Yue Qin, Dehua Wu and Chen Ren
    Citation: Journal of Translational Medicine 2023 21:618
    Content type: Research Published on:

  35. Radiation-induced lung injury (RILI) is a prevalent complication of thoracic radiotherapy in cancer patients. A comprehensive understanding of the underlying mechanisms of RILI is essential for the development...

    Authors: Jianjiao Ni, Tiantian Guo, Yue Zhou, Shanshan Jiang, Long Zhang and Zhengfei Zhu
    Citation: Journal of Translational Medicine 2023 21:590
    Content type: Research Published on:

  36. Tumor hypoxia is associated with resistance to radiotherapy and chemotherapy. In head and neck squamous cell carcinoma (HNSCC), nimorazole, an oxygen mimic, combined with radiotherapy (RT) enabled to improve l...

    Authors: Lydia Koi, Verena Bitto, Corina Weise, Lisa Möbius, Annett Linge, Steffen Löck, Ala Yaromina, María José Besso, Chiara Valentini, Manuel Pfeifer, Jens Overgaard, Daniel Zips, Ina Kurth, Mechthild Krause and Michael Baumann
    Citation: Journal of Translational Medicine 2023 21:576
    Content type: Research Published on:

  37. Primary liver cancer is one of the most common malignant tumours worldwide; it caused approximately 830,000 deaths in 2020. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, accou...

    Authors: Yuhan Yang, Liting Xiong, Mengyuan Li, Ping Jiang, Junjie Wang and Chunxiao Li
    Citation: Journal of Translational Medicine 2023 21:526
    Content type: Review Published on:

  38. Great progress has been made in applying immunotherapy to the clinical treatment of tumors. However, many patients with triple-negative breast cancer (TNBC) cannot benefit from immunotherapy due to the immune ...

    Authors: Hongpei Tan, Jiahao Liu, Jing Huang, Yanan Li, Qiongxuan Xie, Yuqian Dong, Ze Mi, Xiaoqian Ma and Pengfei Rong
    Citation: Journal of Translational Medicine 2023 21:462
    Content type: Research Published on:

  39. Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It’s capacity...

    Authors: Huiyuan Zhang, Yuchen Du, Lin Qi, Sophie Xiao, Frank K. Braun, Mari Kogiso, Yulun Huang, Frank Huang, Aalaa Abdallah, Milagros Suarez, Sekar Karthick, Nabil M. Ahmed, Vita S. Salsman, Patricia A. Baxter, Jack M. Su, Daniel J. Brat…
    Citation: Journal of Translational Medicine 2023 21:444
    Content type: Research Published on:

  40. Osteoradionecrosis (ORN) is a serious complication of radiotherapy for head and neck cancer (HNC). However, its etiology and pathogenesis have not been completely elucidated. Recent studies suggest the involve...

    Authors: Zhengrui Li, Rao Fu, Xufeng Huang, Xutao Wen and Ling Zhang
    Citation: Journal of Translational Medicine 2023 21:391
    Content type: Research Published on:

  41. Tumor cells with the capability of radiation resistance can escape the fate of cell death after radiotherapy, serving as the main cause of treatment failure. Repopulation of tumors after radiotherapy is domina...

    Authors: Yanwei Song, Zheng Deng, Haoran Sun, Yucui Zhao, Ruyi Zhao, Jin Cheng and Qian Huang
    Citation: Journal of Translational Medicine 2023 21:390
    Content type: Research Published on:

  42. Esophageal squamous cell carcinoma (ESCC) is a highly prevalent and aggressive cancer with poor treatment outcomes. Despite the critical role of tight junction proteins in tumorigenesis, the involvement of Cla...

    Authors: Shan Huang, Jiayi Zhang, Yi Li, Yaqiong Xu, Hui Jia, Lei An, Xiaotan Wang and Yuting Yang
    Citation: Journal of Translational Medicine 2023 21:379
    Content type: Research Published on:

  44. Interstitial lung diseases (ILDs) can be induced and even exacerbated by radiotherapy in thoracic cancer patients. The roles of immune responses underlying the development of these severe lung injuries are sti...

    Authors: Xinglong Liu, Liang Zeng, Yuchuan Zhou, Xinrui Zhao, Lin Zhu, Jianghong Zhang, Yan Pan, Chunlin Shao and Jiamei Fu
    Citation: Journal of Translational Medicine 2023 21:314
    Content type: Research Published on:

  45. Recent evidence has shown that immune checkpoint inhibitors (ICIs) are efficacious for treating brain metastases of various primary tumors. However, the immunosuppressive tumor microenvironment and the blood–b...

    Authors: Wentao Tian, Xianjing Chu, Guilong Tanzhu and Rongrong Zhou
    Citation: Journal of Translational Medicine 2023 21:244
    Content type: Review Published on:

  46. The recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains a major clinical problem. Cells that survive the sublethal heat stress that is induced by incomplete RFA are the mai...

    Authors: Chao Peng, Xi Li, Feng Ao, Ting Li, Jingpei Guo, Junfeng Liu, Xiaoting Zhang, Jinyan Gu, Junjie Mao and Bin Zhou
    Citation: Journal of Translational Medicine 2023 21:218
    Content type: Research Published on:

  47. Apurinic/apyrimidinic endonuclease 1 (APE1) imparts radio-resistance by repairing isolated lesions via the base excision repair (BER) pathway, but whether and how it is involved in the formation and/or repair ...

    Authors: Qin Zhang, Lujie Yang, Han Gao, Xunjie Kuang, He Xiao, Chen Yang, Yi Cheng, Lei Zhang, Xin Guo, Yong Zhong and Mengxia Li
    Citation: Journal of Translational Medicine 2023 21:183
    Content type: Research Published on:

  48. Radiotherapy resistance is the main cause of low tumor regression for locally advanced rectum adenocarcinoma (READ). The biomarkers correlated to radiotherapy sensitivity and potential molecular mechanisms hav...

    Authors: Pengfei Zhao, Hongchao Zhen, Hong Zhao, Yongjie Huang and Bangwei Cao
    Citation: Journal of Translational Medicine 2023 21:176
    Content type: Research Published on:

  49. Alpha-emitter radiopharmaceutical therapy (αRPT) has shown promising outcomes in metastatic disease. However, the short range of the alpha particles necessitates dosimetry on a near-cellular spatial scale. Cur...

    Authors: Remco Bastiaannet, Ioanna Liatsou, Robert F Hobbs and George Sgouros
    Citation: Journal of Translational Medicine 2023 21:144
    Content type: Research Published on:

  50. Radiotherapy resistance is the main cause of treatment failure in nasopharyngeal carcinoma (NPC), which leads to poor prognosis. It is urgent to elucidate the molecular mechanisms underlying radiotherapy resis...

    Authors: Enni Chen, Jiajia Huang, Miao Chen, Jiawei Wu, Puyun Ouyang, Xiaonan Wang, Dingbo Shi, Zhiqiao Liu, Wancui Zhu, Haohui Sun, Shanshan Yang, Baoyu Zhang, Wuguo Deng, Huijuan Qiu and Fangyun Xie
    Citation: Journal of Translational Medicine 2023 21:134
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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