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Translational Imaging

Section edited by Ravinder Reddy and Mohammed Haris

The Translational Imaging section provides a platform for rapid dissemination of the advances in medical imaging research emphasizing clinical translation. The topics covered in this section will include methodological innovations in early diagnoses of human diseases and monitoring of therapeutic responses from all the major imaging modalities (MRI, PET, US etc.,). Articles considered for publication include studies in human subjects, pre-clinical models and ex vivo systems dealing with imaging of human pathophysiologies.

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  1. Occult lymph node metastasis (LNM) is a key prognostic factor for patients with head and neck squamous cell carcinoma (HNSCC). This study was to establish radiomics models derived from intratumoral, peritumora...

    Authors: Xinwei Chen, Huan Jiang, Min Pan, Chengmin Feng, Yanshi Li, Lin Chen, Yuxi Luo, Long Liu, Juan Peng and Guohua Hu
    Citation: Journal of Translational Medicine 2025 23:498
  2. Ttyrosine kinase inhibitors (TKIs) represent the standard first-line treatment for patients with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma. However, not all patients with EGFR mutation...

    Authors: Taotao Yang, Xianqi Wang, Yuan Jin, Xiaohong Yao, Zhiyuan Sun, Pinzhen Chen, Suyi Zhou, Wentao Zhu and Wei Chen
    Citation: Journal of Translational Medicine 2025 23:482
  3. Lymph node metastasis (LNM) critically impacts the prognosis and treatment decisions of cervical cancer patients. The accuracy and sensitivity of current imaging techniques, such as CT and MRI, are limited in ...

    Authors: Dongdong Xu, Xibo Zhao, Dongdong Ye, Chuying Huo, Xuanwei Peng, Yunyun Liu and Huaiwu Lu
    Citation: Journal of Translational Medicine 2025 23:397
  4. Non-small cell lung cancer (NSCLC) is highly heterogeneous, leading to varied treatment responses and immune-related adverse reactions (irAEs) among patients. Habitat radiomics allows non-invasive quantitative...

    Authors: Yuemin Wu, Wei Zhang, Xiao Liang, Pengpeng Zhang, Mengzhe Zhang, Yuqin Jiang, Yanan Cui, Yi Chen, Wenxin Zhou, Qi Liang, Jiali Dai, Chen Zhang, Jiali Xu, Jun Li, Tongfu Yu, Zhihong Zhang…
    Citation: Journal of Translational Medicine 2025 23:393
  5. High-grade gliomas are among the most aggressive and deadly brain tumors, highlighting the critical need for improved prognostic markers and predictive models. Recent studies have identified the expression of ...

    Authors: Jie Zhou
    Citation: Journal of Translational Medicine 2025 23:383
  6. Neoadjuvant immunotherapy has been shown to improve survival in patients with gastric cancer. This study sought to develop and validate a radiomics-based machine learning (ML) model for patients with locally a...

    Authors: Ze-Ning Huang, Hao-Xiang Zhang, Yu-Qin Sun, Xing-Qi Zhang, Yi-Fen Lin, Cai-Ming Weng, Chao-Hui Zheng, Ping-Li, Jia-Bin Wang, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chang-Ming Huang, Jian-Xian Lin and Jian-Wei Xie
    Citation: Journal of Translational Medicine 2025 23:362
  7. Activated T cells play a pivotal role in rheumatoid arthritis (RA) pathogenesis, and imaging of activated T cells may provide a non-invasive tool for RA detection. Here, we first developed an optical probe tar...

    Authors: Shao Duan, Chao Li, Feng Yan, Yifei Xia, Shuaiming Shao, Weiyu Chen, Zunyu Xiao and Gongping Xu
    Citation: Journal of Translational Medicine 2025 23:150
  8. Glioblastoma (GBM) is a highly aggressive brain tumor associated with a poor patient prognosis. The survival rate remains low despite standard therapies, highlighting the urgent need for novel treatment strate...

    Authors: Abdul Basit Ahanger, Syed Wajid Aalam, Tariq Ahmad Masoodi, Asma Shah, Meraj Alam Khan, Ajaz A. Bhat, Assif Assad, Muzafar Ahmad Macha and Muzafar Rasool Bhat
    Citation: Journal of Translational Medicine 2025 23:121
  9. Emerging evidence suggests that there are morphological and physiological changes to the vastus lateralis after an anterior cruciate ligament (ACL) tear. However, it is unclear whether these alterations are li...

    Authors: Meredith K. Owen, Lauren Richardson, Darren L. Johnson, Moriel H. Vandsburger, Thorsten Feiweier, Katherine L. Thompson, Christopher S. Fry, Peter A. Hardy and Brian Noehren
    Citation: Journal of Translational Medicine 2025 23:79
  10. With the increasing burden of dental diseases and the limited availability of healthcare resources, traditional triage methods are inadequate in efficiently utilizing healthcare resources and meeting patient n...

    Authors: Yanchan Wu, Tao Yu, Meijia Zhang, Yichen Li, Yijun Wang, Dongren Yang, Yun Yang, Hao Lou, Chufan Ren, Enna Cai, Chenyue Dai, Ruidian Sun, Qiang Xu, Qi Zhao, Huanhuan Zhang and Jiefan Liu
    Citation: Journal of Translational Medicine 2024 22:1123
  11. To develop and validate an online individualized model for predicting local recurrence-free survival (LRFS) in esophageal squamous cell carcinoma (ESCC) treated by definitive chemoradiotherapy (dCRT).

    Authors: Jie Gong, Jianchao Lu, Wencheng Zhang, Wei Huang, Jie Li, Zhi Yang, Fan Meng, Hongfei Sun and Lina Zhao
    Citation: Journal of Translational Medicine 2024 22:1108
  12. There is a growing interest on the association of radiomic features with genomic signatures in oncology. Using computational methods, quantitative radiomic data are extracted from various imaging techniques an...

    Authors: Neila Luciano, Francesca Maria Orlandella, Mariantonia Braile, Carlo Cavaliere, Marco Aiello, Monica Franzese and Giuliana Salvatore
    Citation: Journal of Translational Medicine 2024 22:1088
  13. Accurate differentiation between malignant and benign pulmonary nodules, especially those measuring 5–10 mm in diameter, continues to pose a significant diagnostic challenge. This study introduces a novel, pre...

    Authors: Meng Yang, Huansha Yu, Hongxiang Feng, Jianghui Duan, Kaige Wang, Bing Tong, Yunzhi Zhang, Wei Li, Ye Wang, Chaoyang Liang, Hongliang Sun, Dingrong Zhong, Bei Wang, Huang Chen, Chengxiang Gong, Qiye He…
    Citation: Journal of Translational Medicine 2024 22:984
  14. Surgical resection is integral for the treatment of neuroblastoma, the most common extracranial solid malignancy in children. Safely locating and resecting primary tumor and remote deposits of disease remains ...

    Authors: Lauren Taylor Rosenblum, ReidAnn E. Sever, Ryan Gilbert, David Guerrero, Sarah R. Vincze, Dominic M. Menendez, Peggy A. Birikorang, Mikayla R. Rodgers, Ambika Parmar Jaswal, Alexander C. Vanover, Joseph D. Latoche, Angel G. Cortez, Kathryn E. Day, Lesley M. Foley, Chaim T. Sneiderman, Itay Raphael…
    Citation: Journal of Translational Medicine 2024 22:940
  15. In recent years, digital dentistry has increasingly utilized advanced image analysis techniques, such as image classification and disease diagnosis, to improve clinical outcomes. Despite these advances, the la...

    Authors: Jiaqian Zhu, Li Zeng, Zefei Mo, Luhuan Cao, Yanchan Wu, Liang Hong, Qi Zhao and Feifei Su
    Citation: Journal of Translational Medicine 2024 22:930
  16. CT-detected Extramural venous invasion (EMVI) is known as an independent risk factor for distant metastasis in patients with advanced gastric cancer (GC). However, the molecular basis is not clear. In colorect...

    Authors: Hao Yang, Xinyi Gou, Caizhen Feng, Yuanyuan Zhang, Boshi Sun, Peng Peng, Yi Wang, Nan Hong, Yingjiang Ye, Jin Cheng and Bo Gao
    Citation: Journal of Translational Medicine 2024 22:829
  17. Preoperative prediction of axillary lymph node (ALN) burden in patients with early-stage breast cancer is pivotal for individualised treatment. This study aimed to develop a MRI radiomics model for evaluating ...

    Authors: Minping Hong, Sijia Fan, Zeyan Xu, Zhen Fang, Keng Ling, Penghao Lai, Chaokang Han, Zhonghua Chen, Jie Hou, Yanting Liang, Changyu Zhou, Junyan Wang, Xiaobo Chen, Yanqi Huang and Maosheng Xu
    Citation: Journal of Translational Medicine 2024 22:826
  18. Proliferative hepatocellular carcinomas (HCCs) is a class of aggressive tumors with poor prognosis. We aimed to construct a computed tomography (CT)-based radiomics nomogram to predict proliferative HCC, strat...

    Authors: Gongzheng Wang, Feier Ding, Kaige Chen, Zhuoshuai Liang, Pengxi Han, Linxiang Wang, Fengyun Cui, Qiang Zhu, Zhaoping Cheng, Xingzhi Chen, Chencui Huang, Hongxia Cheng, Ximing Wang and Xinya Zhao
    Citation: Journal of Translational Medicine 2024 22:683
  19. Excessive pericyte coverage promotes tumor growth, and a downregulation may solve this dilemma. Due to the double-edged sword role of vascular pericytes in tumor microenvironment (TME), indiscriminately decrea...

    Authors: Xinpeng Hu, Kunlin Ye, Shaowei Bo, Zeyu Xiao, Mengjie Ma, Jinghua Pan, Xing Zhong, Dong Zhang, Xukai Mo, Xiaojun Yu, Minfeng Chen, Liangping Luo and Changzheng Shi
    Citation: Journal of Translational Medicine 2024 22:712
  20. To provide a preoperative prediction model for lymph node metastasis in pancreatic cancer patients and provide molecular information of key radiomic features.

    Authors: Yi Tang, Yi-xi Su, Jin-mei Zheng, Min-ling Zhuo, Qing-fu Qian, Qing-ling Shen, Peng Lin and Zhi-kui Chen
    Citation: Journal of Translational Medicine 2024 22:690
  21. Breast cancer patients exhibit various response patterns to neoadjuvant chemotherapy (NAC). However, it is uncertain whether diverse tumor response patterns to NAC in breast cancer patients can predict surviva...

    Authors: Ming Fan, Kailang Wang, Da Pan, Xuan Cao, Zhihao Li, Songlin He, Sangma Xie, Chao You, Yajia Gu and Lihua Li
    Citation: Journal of Translational Medicine 2024 22:637
  22. This study developed a nomogram model using CT-based delta-radiomics features and clinical factors to predict pathological complete response (pCR) in esophageal squamous cell carcinoma (ESCC) patients receivin...

    Authors: Liyuan Fan, Zhe Yang, Minghui Chang, Zheng Chen and Qiang Wen
    Citation: Journal of Translational Medicine 2024 22:579
  23. IDH1-wildtype glioblastoma multiforme (IDHwt-GBM) is a highly heterogeneous and aggressive brain tumour characterised by a dismal prognosis and significant challenges in accurately predicting patient outcomes....

    Authors: Qiang Ji, Yi Zheng, Lili Zhou, Feng Chen and Wenbin Li
    Citation: Journal of Translational Medicine 2024 22:578
  24. The purpose of the study was to evaluate the expression and function of basic leucine zipper ATF-like transcription factor (BATF) in colorectal cancer (CRC), and its correlation with 2-deoxy-2[18F]fluoro-d-glucos...

    Authors: Xia Lu, Jun Liu, Lijuan Feng, Yan Huang, Yanfeng Xu, Cuicui Li, Wei Wang, Yin Kan, Jigang Yang and Mingyu Zhang
    Citation: Journal of Translational Medicine 2024 22:558
  25. Neoadjuvant immunochemotherapy (NICT) plus esophagectomy has emerged as a promising treatment option for locally advanced esophageal squamous cell carcinoma (LA-ESCC). Pathologic complete response (pCR) is a k...

    Authors: Yuli Ruan, Yue Ma, Ming Ma, Chao Liu, Dan Su, Xin Guan, Rui Yang, Hong Wang, Tianqin Li, Yang Zhou, Jianqun Ma and Yanqiao Zhang
    Citation: Journal of Translational Medicine 2024 22:471
  26. Cardiometabolic disorders pose significant health risks globally. Metabolic syndrome, characterized by a cluster of potentially reversible metabolic abnormalities, is a known risk factor for these disorders. E...

    Authors: Jacob S. Leiby, Matthew E. Lee, Manu Shivakumar, Eun Kyung Choe and Dokyoon Kim
    Citation: Journal of Translational Medicine 2024 22:434
  27. Programmed cell death 1 (PD-1) belongs to immune checkpoint proteins ensuring negative regulation of the immune response. In non-small cell lung cancer (NSCLC), the sensitivity to treatment with anti-PD-1 ther...

    Authors: Joanna Maria Mierzwicka, Hana Petroková, Leona RaÅ¡ková Kafková, Petr Kosztyu, Jiří ÄŒerný, Milan KuchaÅ™, MiloÅ¡ Petřík, KateÅ™ina Bendová, Kristýna Krasulová, Yaroslava Groza, Lucie Vaňková, Shiv Bharadwaj, Natalya Panova, Michal KÅ™upka, Jozef Å karda, Milan RaÅ¡ka…
    Citation: Journal of Translational Medicine 2024 22:426
  28. The aim of this study is to construct a combined model that integrates radiomics, clinical risk factors and machine learning algorithms to predict para-laryngeal lymph node metastasis in esophageal squamous ce...

    Authors: Ting Xue, Xinyi Wan, Taohu Zhou, Qin Zou, Chao Ma and Jieqiong Chen
    Citation: Journal of Translational Medicine 2024 22:399
  29. In individuals diagnosed with obstructive sleep apnea syndrome (OSAS), variations in craniofacial structure have been inconsistently documented, showing differing degrees of alteration between obese and nonobe...

    Authors: Eugenio Garofalo, Giuseppe Neri, Lucilla Maria Perri, Nicola Lombardo, Giovanna Piazzetta, Alessandro Antonelli, Eugenio Biamonte, Vincenzo Bosco, Caterina Battaglia, Corrado Pelaia, Francesco Manti, Annalisa Pitino, Giovanni Tripepi, Andrea Bruni, Michele Morelli, Amerigo Giudice…
    Citation: Journal of Translational Medicine 2024 22:377
  30. Naturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and are useful models for cancer immunotherapy; but mechanistic data are lacking regarding the ...

    Authors: Simon Deycmar, Brendan J. Johnson, Karina Ray, George W. Schaaf, Declan Patrick Ryan, Cassandra Cullin, Brandy L. Dozier, Betsy Ferguson, Benjamin N. Bimber, John D. Olson, David L. Caudell, Christopher T. Whitlow, Kiran Kumar Solingapuram Sai, Emily C. Romero, Francois J. Villinger, Armando G. Burgos…
    Citation: Journal of Translational Medicine 2024 22:292
  31. Breast Cancer (BC) is a highly heterogeneous and complex disease. Personalized treatment options require the integration of multi-omic data and consideration of phenotypic variability. Radiogenomics aims to me...

    Authors: Zi Huai Huang, Lianghong Chen, Yan Sun, Qian Liu and Pingzhao Hu
    Citation: Journal of Translational Medicine 2024 22:226
  32. Angiogenesis inhibitors have been identified to improve the efficacy of immunotherapy in recent studies. However, the delayed therapeutic effect of immunotherapy poses challenges in treatment planning. Therefo...

    Authors: Xi Xu, Mengjie Ma, Kunlin Ye, Dong Zhang, Xinhui Chen, Jiayang Wu, Xukai Mo, Zeyu Xiao, Changzheng Shi and Liangping Luo
    Citation: Journal of Translational Medicine 2024 22:198
  33. Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. This study aimed to construct immune-related long non-coding RNAs (lncRNAs) signature and radiomics signature to probe ...

    Authors: Jixin Luan, Di Zhang, Bing Liu, Aocai Yang, Kuan Lv, Pianpian Hu, Hongwei Yu, Amir Shmuel, Chuanchen Zhang and Guolin Ma
    Citation: Journal of Translational Medicine 2024 22:107
  34. Identifying precise biomarkers of immunotherapy response for non-small cell lung carcinoma (NSCLC) before treatment is challenging. This study aimed to construct and investigate the potential performance of a ...

    Authors: Jie Peng, Dan Zou, Xudong Zhang, Honglian Ma, Lijie Han and Biao Yao
    Citation: Journal of Translational Medicine 2024 22:87
  35. Hepatocellular carcinoma (HCC) is a common liver malignancy with limited treatment options. Previous studies expressed the potential synergy of sorafenib and NK cell immunotherapy as a promising approach again...

    Authors: Guangbo Yu, Zigeng Zhang, Aydin Eresen, Qiaoming Hou, Emilie Elizabeth Garcia, Zeyang Yu, Nadine Abi-Jaoudeh, Vahid Yaghmai and Zhuoli Zhang
    Citation: Journal of Translational Medicine 2024 22:76
  36. Chest Computed tomography (CT) scans detect lung nodules and assess pulmonary fibrosis. While pulmonary fibrosis indicates increased lung cancer risk, current clinical practice characterizes nodule risk of mal...

    Authors: Yucheng Liu, Hao Yun Hsu, Tiffany Lin, Boyu Peng, Anjali Saqi, Mary M. Salvatore and Sachin Jambawalikar
    Citation: Journal of Translational Medicine 2024 22:51
  37. Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising first-line therapeutics in the management of non-small cell lung cancer (NSCLC). However, only a subset of these patients responds ...

    Authors: Sevinj Yolchuyeva, Leyla Ebrahimpour, Marion Tonneau, Fabien Lamaze, Michele Orain, François Coulombe, Julie Malo, Wiam Belkaid, Bertrand Routy, Philippe Joubert and Venkata SK. Manem
    Citation: Journal of Translational Medicine 2024 22:42
  38. Magnetic resonance fingerprinting (MRF) enables fast myelin quantification via the myelin water fraction (MWF), offering a noninvasive method to assess brain development and disease. However, MRF-derived MWF l...

    Authors: Hyun Gi Kim, Dongyeob Han, Jimin Kim, Jeong-Sun Choi and Kyung-Ok Cho
    Citation: Journal of Translational Medicine 2023 21:914
  39. To develop and validate a conventional MRI-based radiomic model for predicting prognosis in patients with IDH wild-type glioblastoma (GBM) and reveal the biological underpinning of the radiomic phenotypes.

    Authors: Fangzhan Guan, Zilong Wang, Yuning Qiu, Yu Guo, Dongling Pei, Minkai Wang, Aoqi Xing, Zhongyi Liu, Bin Yu, Jingliang Cheng, Xianzhi Liu, Yuchen Ji, Dongming Yan, Jing Yan and Zhenyu Zhang
    Citation: Journal of Translational Medicine 2023 21:841
  40. The recurrence and metastasis of hepatocellular carcinoma (HCC) are mainly caused by microvascular invasion (MVI). Our study aimed to uncover the cellular atlas of MVI+ HCC and investigate the underlying immune i...

    Authors: Yi Wang, Gui-Qi Zhu, Rui Yang, Cheng Wang, Wei-Feng Qu, Tian-Hao Chu, Zheng Tang, Chun Yang, Li Yang, Chang-Wu Zhou, Geng-Yun Miao, Wei-Ren Liu, Ying-Hong Shi and Meng-Su Zeng
    Citation: Journal of Translational Medicine 2023 21:734
  41. Gastrointestinal stromal tumors (GISTs) carrying different KIT exon 11 (KIT-11) mutations exhibit varying prognoses and responses to Imatinib. Herein, we aimed to determine whether computed tomography (CT) rad...

    Authors: Qing-Wei Zhang, Ran-Ying Zhang, Zhi-Bo Yan, Yu-Xuan Zhao, Xin-Yuan Wang, Jing-Zheng Jin, Qi-Xuan Qiu, Jie-Jun Chen, Zhen-Hui Xie, Jiang Lin, Hui Cao, Yan Zhou, Hui-Min Chen and Xiao-Bo Li
    Citation: Journal of Translational Medicine 2023 21:726
  42. The advent of immunotherapy, a groundbreaking advancement in cancer treatment, has given rise to the prominence of the tumor microenvironment (TME) as a critical area of research. The clinical implications of ...

    Authors: Wendi Kang, Xiang Qiu, Yingen Luo, Jianwei Luo, Yang Liu, Junqing Xi, Xiao Li and Zhengqiang Yang
    Citation: Journal of Translational Medicine 2023 21:598
  43. With metabolic alterations of the tumor microenvironment (TME) contributing to cancer progression, metastatic spread and response to targeted therapies, non-invasive and repetitive imaging of tumor metabolism ...

    Authors: Emily Hoffmann, Daniel Schache, Carsten Höltke, Jens Soltwisch, Stephan Niland, Tobias Krähling, Klaus Bergander, Martin Grewer, Christiane Geyer, Linda Groeneweg, Johannes A. Eble, Thomas Vogl, Johannes Roth, Walter Heindel, Bastian Maus, Anne Helfen…
    Citation: Journal of Translational Medicine 2023 21:577
  44. This study investigated the correlation between the expression of DARS2 and metabolic parameters of 18F-FDG PET/CT, and explored the potential mechanisms of DARS2 affecting the proliferation and glycolysis of lun...

    Authors: Xu-Sheng Liu, Ling-Ling Yuan, Yan Gao, Xing Ming, Yao-Hua Zhang, Yu Zhang, Zi-Yue Liu, Yi Yang and Zhi-Jun Pei
    Citation: Journal of Translational Medicine 2023 21:574
  45. The ventral tegmental area (VTA) contains heterogeneous cell populations. The dopaminergic neurons in VTA play a central role in reward and cognition, while CamKIIα-positive neurons, composed mainly of glutama...

    Authors: Ning Zheng, Zhu Gui, Xiaodong Liu, Yang Wu, Huadong Wang, Aoling Cai, Jinfeng Wu, Xihai Li, Challika Kaewborisuth, Zhijian Zhang, Qitian Wang, Anne Manyande, Fuqiang Xu and Jie Wang
    Citation: Journal of Translational Medicine 2023 21:543
  46. Finding a noninvasive radiomic surrogate of tumor immune features could help identify patients more likely to respond to novel immune checkpoint inhibitors. Particularly, CD73 is an ectonucleotidase that catal...

    Authors: Ralph Saber, David Henault, Nouredin Messaoudi, Rolando Rebolledo, Emmanuel Montagnon, Geneviève Soucy, John Stagg, An Tang, Simon Turcotte and Samuel Kadoury
    Citation: Journal of Translational Medicine 2023 21:507
  47. Glioma grade 4 (GG4) tumors, including astrocytoma IDH-mutant grade 4 and the astrocytoma IDH wt are the most common and aggressive primary tumors of the central nervous system. Surgery followed by Stupp proto...

    Authors: Michele Dal Bo, Maurizio Polano, Tamara Ius, Federica Di Cintio, Alessia Mondello, Ivana Manini, Enrico Pegolo, Daniela Cesselli, Carla Di Loreto, Miran Skrap and Giuseppe Toffoli
    Citation: Journal of Translational Medicine 2023 21:450
  48. Chimeric antigen receptor (CAR) T cell therapy is an exciting cell-based cancer immunotherapy. Unfortunately, CAR-T cell therapy is associated with serious toxicities such as cytokine release syndrome (CRS) an...

    Authors: Pamela Leland, Dhiraj Kumar, Sridhar Nimmagadda, Steven R. Bauer, Raj K. Puri and Bharat H. Joshi
    Citation: Journal of Translational Medicine 2023 21:367

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:636

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